Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

The CD1-restricted T-cell response to mycobacteria.

Authors: Authors: Moody DB, Sugita M, Peters PJ, Brenner MB, Porcelli SA.
Res Immunol 1996-01-01
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Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements.

Authors: Authors: Sleckman BP, Gorman JR, Alt FW.
Annu Rev Immunol 1996-01-01
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The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination.

Authors: Authors: Li Z, Otevrel T, Gao Y, Cheng HL, Seed B, Stamato TD, Taccioli GE, Alt FW.
Cell 1995-12-29
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A pathway of costimulation that prevents anergy in CD28- T cells: B7-independent costimulation of CD1-restricted T cells.

Authors: Authors: Behar SM, Porcelli SA, Beckman EM, Brenner MB.
J Exp Med 1995-12-01
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Promotion of V(D)J recombinational accessibility by the intronic E kappa element: role of the kappa B motif.

Authors: Authors: Demengeot J, Oltz EM, Alt FW.
Int Immunol 1995-12-01
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A YAC contig encompassing the XRCC5 (Ku80) DNA repair gene and complementation of defective cells by YAC protoplast fusion.

Authors: Authors: Blunt T, Taccioli GE, Priestley A, Hafezparast M, McMillan T, Liu J, Cole CC, White J, Alt FW, Jackson SP, et al.
Genomics 1995-11-20
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Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene.

Authors: Authors: Bories JC, Willerford DM, Grévin D, Davidson L, Camus A, Martin P, Stéhelin D, Alt FW.
Nature 1995-10-19
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The role of short homology repeats and TdT in generation of the invariant gamma delta antigen receptor repertoire in the fetal thymus.

Authors: Authors: Zhang Y, Cado D, Asarnow DM, Komori T, Alt FW, Raulet DH, Allison JP.
Immunity 1995-10-01
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Generation of normal lymphocytes derived from N-myc-deficient embryonic stem cells.

Authors: Authors: Malynn BA, Demengeot J, Stewart V, Charron J, Alt FW.
Int Immunol 1995-10-01
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Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment.

Authors: Authors: Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW.
Immunity 1995-10-01
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