Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells.
Authors: Authors: Morita CT, Beckman EM, Bukowski JF, Tanaka Y, Band H, Bloom BR, Golan DE, Brenner MB.
Immunity
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The role of short homology repeats and TdT in generation of the invariant gamma delta antigen receptor repertoire in the fetal thymus.
Authors: Authors: Zhang Y, Cado D, Asarnow DM, Komori T, Alt FW, Raulet DH, Allison JP.
Immunity
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Generation of normal lymphocytes derived from N-myc-deficient embryonic stem cells.
Authors: Authors: Malynn BA, Demengeot J, Stewart V, Charron J, Alt FW.
Int Immunol
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Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment.
Authors: Authors: Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW.
Immunity
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Bone marrow B lymphocyte development in c-abl-deficient mice.
Authors: Authors: Hardin JD, Boast S, Schwartzberg PL, Lee G, Alt FW, Stall AM, Goff SP.
Cell Immunol
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The beta 7 integrins in mucosal homing and retention.
Authors: Authors: Shaw SK, Brenner MB.
Semin Immunol
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The role of Bruton's tyrosine kinase in B-cell development and function in mice and man.
Authors: Authors: Khan WN, Sideras P, Rosen FS, Alt FW.
Ann N Y Acad Sci
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Defective B cell development and function in Btk-deficient mice.
Authors: Authors: Khan WN, Alt FW, Gerstein RM, Malynn BA, Larsson I, Rathbun G, Davidson L, Müller S, Kantor AB, Herzenberg LA, et al.
Immunity
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Potential targets for autosomal SCID mutations.
Authors: Authors: Taccioli GE, Alt FW.
Curr Opin Immunol
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CD1-restricted T cell recognition of microbial lipoglycan antigens.
Authors: Authors: Sieling PA, Chatterjee D, Porcelli SA, Prigozy TI, Mazzaccaro RJ, Soriano T, Bloom BR, Brenner MB, Kronenberg M, Brennan PJ, et al.
Science
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