Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Expansions of V alpha 12 CD8+ T-cells in rheumatoid arthritis.
Authors: Authors: Behar SM, Roy C, Brenner MB.
Ann N Y Acad Sci
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T-cell receptor V beta gene usage in rheumatoid synovial follicles.
Authors: Authors: Travaglio-Encinozal A, Dersimonian H, Jorgensen C, Romagné F, Sany J, D'Angeac AD, Brenner MB, Rème T.
Ann N Y Acad Sci
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MHC class I-like, class II-like and CD1 molecules: distinct roles in immunity.
Authors: Authors: Beckman EM, Brenner MB.
Immunol Today
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Bclx regulates the survival of double-positive thymocytes.
Authors: Authors: Ma A, Pena JC, Chang B, Margosian E, Davidson L, Alt FW, Thompson CB.
Proc Natl Acad Sci U S A
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Natural and synthetic non-peptide antigens recognized by human gamma delta T cells.
Authors: Authors: Tanaka Y, Morita CT, Tanaka Y, Nieves E, Brenner MB, Bloom BR.
Nature
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CD3 epsilon and CD3 zeta cytoplasmic domains can independently generate signals for T cell development and function.
Authors: Authors: Shinkai Y, Ma A, Cheng HL, Alt FW.
Immunity
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Expression and induction of nuclear factor-kappa B-related proteins in thymocytes.
Authors: Authors: Sen J, Venkataraman L, Shinkai Y, Pierce JW, Alt FW, Burakoff SJ, Sen R.
J Immunol
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Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene.
Authors: Authors: Zhang R, Alt FW, Davidson L, Orkin SH, Swat W.
Nature
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Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.
Authors: Authors: Blunt T, Finnie NJ, Taccioli GE, Smith GC, Demengeot J, Gottlieb TM, Mizuta R, Varghese AJ, Alt FW, Jeggo PA, Jackson SP.
Cell
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T cell receptor distribution in rheumatoid synovial follicles.
Authors: Authors: Travaglio-Encinoza A, Chaouni I, Dersimonian H, Jorgensen C, Simony-Lafontaine J, Romagné F, Sany J, Dupuy d'Angeac AD, Brenner MB, Rème T.
J Rheumatol
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