Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

The role of Bruton's tyrosine kinase in B-cell development and function in mice and man.

Authors: Authors: Khan WN, Sideras P, Rosen FS, Alt FW.
Ann N Y Acad Sci 1995-09-29
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Defective B cell development and function in Btk-deficient mice.

Authors: Authors: Khan WN, Alt FW, Gerstein RM, Malynn BA, Larsson I, Rathbun G, Davidson L, Müller S, Kantor AB, Herzenberg LA, et al.
Immunity 1995-09-01
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Potential targets for autosomal SCID mutations.

Authors: Authors: Taccioli GE, Alt FW.
Curr Opin Immunol 1995-08-01
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CD1-restricted T cell recognition of microbial lipoglycan antigens.

Authors: Authors: Sieling PA, Chatterjee D, Porcelli SA, Prigozy TI, Mazzaccaro RJ, Soriano T, Bloom BR, Brenner MB, Kronenberg M, Brennan PJ, et al.
Science 1995-07-14
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Expansions of V alpha 12 CD8+ T-cells in rheumatoid arthritis.

Authors: Authors: Behar SM, Roy C, Brenner MB.
Ann N Y Acad Sci 1995-07-07
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T-cell receptor V beta gene usage in rheumatoid synovial follicles.

Authors: Authors: Travaglio-Encinozal A, Dersimonian H, Jorgensen C, Romagné F, Sany J, D'Angeac AD, Brenner MB, Rème T.
Ann N Y Acad Sci 1995-07-07
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MHC class I-like, class II-like and CD1 molecules: distinct roles in immunity.

Authors: Authors: Beckman EM, Brenner MB.
Immunol Today 1995-07-01
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Bclx regulates the survival of double-positive thymocytes.

Authors: Authors: Ma A, Pena JC, Chang B, Margosian E, Davidson L, Alt FW, Thompson CB.
Proc Natl Acad Sci U S A 1995-05-23
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Natural and synthetic non-peptide antigens recognized by human gamma delta T cells.

Authors: Authors: Tanaka Y, Morita CT, Tanaka Y, Nieves E, Brenner MB, Bloom BR.
Nature 1995-05-11
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CD3 epsilon and CD3 zeta cytoplasmic domains can independently generate signals for T cell development and function.

Authors: Authors: Shinkai Y, Ma A, Cheng HL, Alt FW.
Immunity 1995-04-01
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