Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

CD3 epsilon and CD3 zeta cytoplasmic domains can independently generate signals for T cell development and function.
Authors: Authors: Shinkai Y, Ma A, Cheng HL, Alt FW.
Immunity
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Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene.
Authors: Authors: Zhang R, Alt FW, Davidson L, Orkin SH, Swat W.
Nature
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Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.
Authors: Authors: Blunt T, Finnie NJ, Taccioli GE, Smith GC, Demengeot J, Gottlieb TM, Mizuta R, Varghese AJ, Alt FW, Jeggo PA, Jackson SP.
Cell
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T cell receptor distribution in rheumatoid synovial follicles.
Authors: Authors: Travaglio-Encinoza A, Chaouni I, Dersimonian H, Jorgensen C, Simony-Lafontaine J, Romagné F, Sany J, Dupuy d'Angeac AD, Brenner MB, Rème T.
J Rheumatol
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V gamma 2V delta 2 TCR-dependent recognition of non-peptide antigens and Daudi cells analyzed by TCR gene transfer.
Authors: Authors: Bukowski JF, Morita CT, Tanaka Y, Bloom BR, Brenner MB, Band H.
J Immunol
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Association of the invariant chain with major histocompatibility complex class I molecules directs trafficking to endocytic compartments.
Authors: Authors: Sugita M, Brenner MB.
J Biol Chem
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Recognition of a lipid antigen by CD1-restricted alpha beta+ T cells.
Authors: Authors: Beckman EM, Porcelli SA, Morita CT, Behar SM, Furlong ST, Brenner MB.
Nature
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CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.
Authors: Authors: Castigli E, Alt FW, Davidson L, Bottaro A, Mizoguchi E, Bhan AK, Geha RS.
Proc Natl Acad Sci U S A
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Antibody response elicited by T-dependent and T-independent antigens in gene targeted kappa-deficient mice.
Authors: Authors: Pricop L, Brumeanu T, Elahi E, Moran T, Wang BS, Troustine M, Huszar D, Alt F, Bona C.
Int Immunol
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Nuclear factors that mediate intrathymic signals are developmentally regulated.
Authors: Authors: Sen J, Shinkai Y, Alt FW, Sen R, Burakoff SJ.
J Exp Med
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