Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

V gamma 2V delta 2 TCR-dependent recognition of non-peptide antigens and Daudi cells analyzed by TCR gene transfer.
Authors: Authors: Bukowski JF, Morita CT, Tanaka Y, Bloom BR, Brenner MB, Band H.
J Immunol
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Association of the invariant chain with major histocompatibility complex class I molecules directs trafficking to endocytic compartments.
Authors: Authors: Sugita M, Brenner MB.
J Biol Chem
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Recognition of a lipid antigen by CD1-restricted alpha beta+ T cells.
Authors: Authors: Beckman EM, Porcelli SA, Morita CT, Behar SM, Furlong ST, Brenner MB.
Nature
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CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.
Authors: Authors: Castigli E, Alt FW, Davidson L, Bottaro A, Mizoguchi E, Bhan AK, Geha RS.
Proc Natl Acad Sci U S A
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An unstable beta 2-microglobulin: major histocompatibility complex class I heavy chain intermediate dissociates from calnexin and then is stabilized by binding peptide.
Authors: Authors: Sugita M, Brenner MB.
J Exp Med
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Antibody response elicited by T-dependent and T-independent antigens in gene targeted kappa-deficient mice.
Authors: Authors: Pricop L, Brumeanu T, Elahi E, Moran T, Wang BS, Troustine M, Huszar D, Alt F, Bona C.
Int Immunol
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Nuclear factors that mediate intrathymic signals are developmentally regulated.
Authors: Authors: Sen J, Shinkai Y, Alt FW, Sen R, Burakoff SJ.
J Exp Med
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Recognition and destruction of virus-infected cells by human gamma delta CTL.
Authors: Authors: Bukowski JF, Morita CT, Brenner MB.
J Immunol
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Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin.
Authors: Authors: Cepek KL, Shaw SK, Parker CM, Russell GJ, Morrow JS, Rimm DL, Brenner MB.
Nature
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TCR usage and functional capabilities of human gamma delta T cells at birth.
Authors: Authors: Morita CT, Parker CM, Brenner MB, Band H.
J Immunol
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