Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Distinct structural and functional epitopes of the alpha E beta 7 integrin.

Authors: Authors: Russell GJ, Parker CM, Cepek KL, Mandelbrot DA, Sood A, Mizoguchi E, Ebert EC, Brenner MB, Bhan AK.
Eur J Immunol 1994-11-01
View full abstract on Pubmed

An early haematopoietic defect in mice lacking the transcription factor GATA-2.

Authors: Authors: Tsai FY, Keller G, Kuo FC, Weiss M, Chen J, Rosenblatt M, Alt FW, Orkin SH.
Nature 1994-09-15
View full abstract on Pubmed

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination.

Authors: Authors: Taccioli GE, Gottlieb TM, Blunt T, Priestley A, Demengeot J, Mizuta R, Lehmann AR, Alt FW, Jackson SP, Jeggo PA.
Science 1994-09-02
View full abstract on Pubmed

Nonpeptide ligands for human gamma delta T cells.

Authors: Authors: Tanaka Y, Sano S, Nieves E, De Libero G, Rosa D, Modlin RL, Brenner MB, Bloom BR, Morita CT.
Proc Natl Acad Sci U S A 1994-08-16
View full abstract on Pubmed

Murine M290 integrin expression modulated by mast cell activation.

Authors: Authors: Smith TJ, Ducharme LA, Shaw SK, Parker CM, Brenner MB, Kilshaw PJ, Weis JH.
Immunity 1994-08-01
View full abstract on Pubmed

Reconstitution of cultured intestinal epithelial monolayers with a mucosal-derived T lymphocyte cell line. Modulation of epithelial phenotype dependent on lymphocyte-basolateral membrane apposition.

Authors: Authors: Kaoutzani P, Colgan SP, Cepek KL, Burkard PG, Carlson S, Delp-Archer C, Brenner MB, Madara JL.
J Clin Invest 1994-08-01
View full abstract on Pubmed

IL-2 receptor alpha chain expression during early B lymphocyte differentiation.

Authors: Authors: Chen J, Ma A, Young F, Alt FW.
Int Immunol 1994-08-01
View full abstract on Pubmed

Calnexin retains unassembled major histocompatibility complex class I free heavy chains in the endoplasmic reticulum.

Authors: Authors: Rajagopalan S, Brenner MB.
J Exp Med 1994-07-01
View full abstract on Pubmed

Differential activation of transcription versus recombination of transgenic T cell receptor beta variable region gene segments in B and T lineage cells.

Authors: Authors: Okada A, Mendelsohn M, Alt F.
J Exp Med 1994-07-01
View full abstract on Pubmed

CD3 epsilon-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2-/- mice in the absence of TCR beta chain expression.

Authors: Authors: Shinkai Y, Alt FW.
Int Immunol 1994-07-01
View full abstract on Pubmed