Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Recognition and destruction of virus-infected cells by human gamma delta CTL.

Authors: Authors: Bukowski JF, Morita CT, Brenner MB.
J Immunol 1994-12-01
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An unstable beta 2-microglobulin: major histocompatibility complex class I heavy chain intermediate dissociates from calnexin and then is stabilized by binding peptide.

Authors: Authors: Sugita M, Brenner MB.
J Exp Med 1994-12-01
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Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin.

Authors: Authors: Cepek KL, Shaw SK, Parker CM, Russell GJ, Morrow JS, Rimm DL, Brenner MB.
Nature 1994-11-10
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Distinct structural and functional epitopes of the alpha E beta 7 integrin.

Authors: Authors: Russell GJ, Parker CM, Cepek KL, Mandelbrot DA, Sood A, Mizoguchi E, Ebert EC, Brenner MB, Bhan AK.
Eur J Immunol 1994-11-01
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TCR usage and functional capabilities of human gamma delta T cells at birth.

Authors: Authors: Morita CT, Parker CM, Brenner MB, Band H.
J Immunol 1994-11-01
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An early haematopoietic defect in mice lacking the transcription factor GATA-2.

Authors: Authors: Tsai FY, Keller G, Kuo FC, Weiss M, Chen J, Rosenblatt M, Alt FW, Orkin SH.
Nature 1994-09-15
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Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination.

Authors: Authors: Taccioli GE, Gottlieb TM, Blunt T, Priestley A, Demengeot J, Mizuta R, Lehmann AR, Alt FW, Jackson SP, Jeggo PA.
Science 1994-09-02
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Nonpeptide ligands for human gamma delta T cells.

Authors: Authors: Tanaka Y, Sano S, Nieves E, De Libero G, Rosa D, Modlin RL, Brenner MB, Bloom BR, Morita CT.
Proc Natl Acad Sci U S A 1994-08-16
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Murine M290 integrin expression modulated by mast cell activation.

Authors: Authors: Smith TJ, Ducharme LA, Shaw SK, Parker CM, Brenner MB, Kilshaw PJ, Weis JH.
Immunity 1994-08-01
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Reconstitution of cultured intestinal epithelial monolayers with a mucosal-derived T lymphocyte cell line. Modulation of epithelial phenotype dependent on lymphocyte-basolateral membrane apposition.

Authors: Authors: Kaoutzani P, Colgan SP, Cepek KL, Burkard PG, Carlson S, Delp-Archer C, Brenner MB, Madara JL.
J Clin Invest 1994-08-01
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