Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

A class switch control region at the 3' end of the immunoglobulin heavy chain locus.

Authors: Authors: Cogné M, Lansford R, Bottaro A, Zhang J, Gorman J, Young F, Cheng HL, Alt FW.
Cell 1994-06-03
View full abstract on Pubmed

Mechanisms that control antigen receptor variable region gene assembly.

Authors: Authors: Okada A, Alt FW.
Semin Immunol 1994-06-01
View full abstract on Pubmed

Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation.

Authors: Authors: Young F, Ardman B, Shinkai Y, Lansford R, Blackwell TK, Mendelsohn M, Rolink A, Melchers F, Alt FW.
Genes Dev 1994-05-01
View full abstract on Pubmed

The expression of Vpre-B/lambda 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice.

Authors: Authors: Karasuyama H, Rolink A, Shinkai Y, Young F, Alt FW, Melchers F.
Cell 1994-04-08
View full abstract on Pubmed

Generation of normal T and B lymphocytes by c-jun deficient embryonic stem cells.

Authors: Authors: Chen J, Stewart V, Spyrou G, Hilberg F, Wagner EF, Alt FW.
Immunity 1994-04-01
View full abstract on Pubmed

Probing immune functions in RAG-deficient mice.

Authors: Authors: Chen J, Shinkai Y, Young F, Alt FW.
Curr Opin Immunol 1994-04-01
View full abstract on Pubmed

Expression of I mu-C gamma hybrid germline transcripts subsequent to immunoglobulin heavy chain class switching.

Authors: Authors: Li SC, Rothman PB, Zhang J, Chan C, Hirsh D, Alt FW.
Int Immunol 1994-04-01
View full abstract on Pubmed

Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution.

Authors: Authors: Shaw SK, Cepek KL, Murphy EA, Russell GJ, Brenner MB, Parker CM.
J Biol Chem 1994-03-25
View full abstract on Pubmed

A DNA repair defect in Chinese hamster ovary cells affects V(D)J recombination similarly to the murine scid mutation.

Authors: Authors: Taccioli GE, Cheng HL, Varghese AJ, Whitmore G, Alt FW.
J Biol Chem 1994-03-11
View full abstract on Pubmed

Calnexin: a membrane-bound chaperone of the endoplasmic reticulum.

Authors: Authors: Bergeron JJ, Brenner MB, Thomas DY, Williams DB.
Trends Biochem Sci 1994-03-01
View full abstract on Pubmed