Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Reconstitution of cultured intestinal epithelial monolayers with a mucosal-derived T lymphocyte cell line. Modulation of epithelial phenotype dependent on lymphocyte-basolateral membrane apposition.
Authors: Authors: Kaoutzani P, Colgan SP, Cepek KL, Burkard PG, Carlson S, Delp-Archer C, Brenner MB, Madara JL.
J Clin Invest
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Differential activation of transcription versus recombination of transgenic T cell receptor beta variable region gene segments in B and T lineage cells.
Authors: Authors: Okada A, Mendelsohn M, Alt F.
J Exp Med
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CD3 epsilon-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2-/- mice in the absence of TCR beta chain expression.
Authors: Authors: Shinkai Y, Alt FW.
Int Immunol
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Calnexin retains unassembled major histocompatibility complex class I free heavy chains in the endoplasmic reticulum.
Authors: Authors: Rajagopalan S, Brenner MB.
J Exp Med
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A class switch control region at the 3' end of the immunoglobulin heavy chain locus.
Authors: Authors: Cogné M, Lansford R, Bottaro A, Zhang J, Gorman J, Young F, Cheng HL, Alt FW.
Cell
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Mechanisms that control antigen receptor variable region gene assembly.
Authors: Authors: Okada A, Alt FW.
Semin Immunol
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Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation.
Authors: Authors: Young F, Ardman B, Shinkai Y, Lansford R, Blackwell TK, Mendelsohn M, Rolink A, Melchers F, Alt FW.
Genes Dev
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The expression of Vpre-B/lambda 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice.
Authors: Authors: Karasuyama H, Rolink A, Shinkai Y, Young F, Alt FW, Melchers F.
Cell
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Generation of normal T and B lymphocytes by c-jun deficient embryonic stem cells.
Authors: Authors: Chen J, Stewart V, Spyrou G, Hilberg F, Wagner EF, Alt FW.
Immunity
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Probing immune functions in RAG-deficient mice.
Authors: Authors: Chen J, Shinkai Y, Young F, Alt FW.
Curr Opin Immunol
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