Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Evidence for a structural difference in the CD7 polypeptide on human thymocytes and intraepithelial lymphocytes defined by a new monoclonal antibody, 3D9.

Authors: Authors: Russell GJ, Parker CM, Cepek KL, Brenner MB, Bhan AK.
Cell Immunol 1994-03-01
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S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process.

Authors: Authors: Bottaro A, Lansford R, Xu L, Zhang J, Rothman P, Alt FW.
EMBO J 1994-02-01
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Retention of unassembled components of integral membrane proteins by calnexin.

Authors: Authors: Rajagopalan S, Xu Y, Brenner MB.
Science 1994-01-21
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Intact antiinfluenza virus immune response in targeted kappa-deficient mice.

Authors: Authors: Isobe H, Alt F, Bona CA, Schulman J.
Viral Immunol 1994-01-01
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Class II histocompatibility molecules associate with calnexin during assembly in the endoplasmic reticulum.

Authors: Authors: Schreiber KL, Bell MP, Huntoon CJ, Rajagopalan S, Brenner MB, McKean DJ.
Int Immunol 1994-01-01
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Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.

Authors: Authors: Chen J, Young F, Bottaro A, Stewart V, Smith RK, Alt FW.
EMBO J 1993-12-01
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A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination.

Authors: Authors: Oltz EM, Alt FW, Lin WC, Chen J, Taccioli G, Desiderio S, Rathbun G.
Mol Cell Biol 1993-10-01
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Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice.

Authors: Authors: Nakayama K, Nakayama K, Negishi I, Kuida K, Shinkai Y, Louie MC, Fields LE, Lucas PJ, Stewart V, Alt FW, et al.
Science 1993-09-17
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Binding of myc proteins to canonical and noncanonical DNA sequences.

Authors: Authors: Blackwell TK, Huang J, Ma A, Kretzner L, Alt FW, Eisenman RN, Weintraub H.
Mol Cell Biol 1993-09-01
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A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon.

Authors: Authors: Zhang J, Bottaro A, Li S, Stewart V, Alt FW.
EMBO J 1993-09-01
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