Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes.
Authors: Authors: Komori T, Okada A, Stewart V, Alt FW.
Science
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Comparison of RAG gene expression in normal and transformed precursor lymphocytes.
Authors: Authors: Rathbun G, Oltz EM, Alt FW.
Int Immunol
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Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain.
Authors: Authors: Porcelli S, Yockey CE, Brenner MB, Balk SP.
J Exp Med
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Generation of normal lymphocyte populations by Rb-deficient embryonic stem cells.
Authors: Authors: Chen J, Gorman JR, Stewart V, Williams B, Jacks T, Alt FW.
Curr Biol
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Clonal V alpha 12.1+ T cell expansions in the peripheral blood of rheumatoid arthritis patients.
Authors: Authors: DerSimonian H, Sugita M, Glass DN, Maier AL, Weinblatt ME, Rème T, Brenner MB.
J Exp Med
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Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus.
Authors: Authors: Chen J, Trounstine M, Alt FW, Young F, Kurahara C, Loring JF, Huszar D.
Int Immunol
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RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.
Authors: Authors: Chen J, Lansford R, Stewart V, Young F, Alt FW.
Proc Natl Acad Sci U S A
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Interaction with newly synthesized and retained proteins in the endoplasmic reticulum suggests a chaperone function for human integral membrane protein IP90 (calnexin).
Authors: Authors: David V, Hochstenbach F, Rajagopalan S, Brenner MB.
J Biol Chem
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Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching.
Authors: Authors: Xu L, Gorham B, Li SC, Bottaro A, Alt FW, Rothman P.
Proc Natl Acad Sci U S A
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Integrin alpha E beta 7 mediates adhesion of T lymphocytes to epithelial cells.
Authors: Authors: Cepek KL, Parker CM, Madara JL, Brenner MB.
J Immunol
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