Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.

Authors: Authors: Chen J, Lansford R, Stewart V, Young F, Alt FW.
Proc Natl Acad Sci U S A 1993-05-15
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Interaction with newly synthesized and retained proteins in the endoplasmic reticulum suggests a chaperone function for human integral membrane protein IP90 (calnexin).

Authors: Authors: David V, Hochstenbach F, Rajagopalan S, Brenner MB.
J Biol Chem 1993-05-05
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Integrin alpha E beta 7 mediates adhesion of T lymphocytes to epithelial cells.

Authors: Authors: Cepek KL, Parker CM, Madara JL, Brenner MB.
J Immunol 1993-04-15
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Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching.

Authors: Authors: Xu L, Gorham B, Li SC, Bottaro A, Alt FW, Rothman P.
Proc Natl Acad Sci U S A 1993-04-15
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Impairment of V(D)J recombination in double-strand break repair mutants.

Authors: Authors: Taccioli GE, Rathbun G, Oltz E, Stamato T, Jeggo PA, Alt FW.
Science 1993-04-09
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Alpha 4/180, a novel form of the integrin alpha 4 subunit.

Authors: Authors: Parker CM, Pujades C, Brenner MB, Hemler ME.
J Biol Chem 1993-04-05
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Fc gamma RII/III and CD2 expression mark distinct subpopulations of immature CD4-CD8- murine thymocytes: in vivo developmental kinetics and T cell receptor beta chain rearrangement status.

Authors: Authors: Rodewald HR, Awad K, Moingeon P, D'Adamio L, Rabinowitz D, Shinkai Y, Alt FW, Reinherz EL.
J Exp Med 1993-04-01
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Gene rearrangement and B-cell development.

Authors: Authors: Chen J, Alt FW.
Curr Opin Immunol 1993-04-01
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DNA binding by N- and L-Myc proteins.

Authors: Authors: Ma A, Moroy T, Collum R, Weintraub H, Alt FW, Blackwell TK.
Oncogene 1993-04-01
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B cell development in mice that lack one or both immunoglobulin kappa light chain genes.

Authors: Authors: Chen J, Trounstine M, Kurahara C, Young F, Kuo CC, Xu Y, Loring JF, Alt FW, Huszar D.
EMBO J 1993-03-01
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