Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Impairment of V(D)J recombination in double-strand break repair mutants.

Authors: Authors: Taccioli GE, Rathbun G, Oltz E, Stamato T, Jeggo PA, Alt FW.
Science 1993-04-09
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Alpha 4/180, a novel form of the integrin alpha 4 subunit.

Authors: Authors: Parker CM, Pujades C, Brenner MB, Hemler ME.
J Biol Chem 1993-04-05
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Fc gamma RII/III and CD2 expression mark distinct subpopulations of immature CD4-CD8- murine thymocytes: in vivo developmental kinetics and T cell receptor beta chain rearrangement status.

Authors: Authors: Rodewald HR, Awad K, Moingeon P, D'Adamio L, Rabinowitz D, Shinkai Y, Alt FW, Reinherz EL.
J Exp Med 1993-04-01
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Gene rearrangement and B-cell development.

Authors: Authors: Chen J, Alt FW.
Curr Opin Immunol 1993-04-01
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DNA binding by N- and L-Myc proteins.

Authors: Authors: Ma A, Moroy T, Collum R, Weintraub H, Alt FW, Blackwell TK.
Oncogene 1993-04-01
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B cell development in mice that lack one or both immunoglobulin kappa light chain genes.

Authors: Authors: Chen J, Trounstine M, Kurahara C, Young F, Kuo CC, Xu Y, Loring JF, Alt FW, Huszar D.
EMBO J 1993-03-01
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Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes.

Authors: Authors: Shinkai Y, Koyasu S, Nakayama K, Murphy KM, Loh DY, Reinherz EL, Alt FW.
Science 1993-02-05
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LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells.

Authors: Authors: Xu Y, Baldassare M, Fisher P, Rathbun G, Oltz EM, Yancopoulos GD, Jessell TM, Alt FW.
Proc Natl Acad Sci U S A 1993-01-01
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CD1b restricts the response of human CD4-8- T lymphocytes to a microbial antigen.

Authors: Authors: Porcelli S, Morita CT, Brenner MB.
Nature 1992-12-10
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Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene.

Authors: Authors: Charron J, Malynn BA, Fisher P, Stewart V, Jeannotte L, Goff SP, Robertson EJ, Alt FW.
Genes Dev 1992-12-01
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