Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes.

Authors: Authors: Shinkai Y, Koyasu S, Nakayama K, Murphy KM, Loh DY, Reinherz EL, Alt FW.
Science 1993-02-05
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LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells.

Authors: Authors: Xu Y, Baldassare M, Fisher P, Rathbun G, Oltz EM, Yancopoulos GD, Jessell TM, Alt FW.
Proc Natl Acad Sci U S A 1993-01-01
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CD1b restricts the response of human CD4-8- T lymphocytes to a microbial antigen.

Authors: Authors: Porcelli S, Morita CT, Brenner MB.
Nature 1992-12-10
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Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene.

Authors: Authors: Charron J, Malynn BA, Fisher P, Stewart V, Jeannotte L, Goff SP, Robertson EJ, Alt FW.
Genes Dev 1992-12-01
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VDJ recombination.

Authors: Authors: Alt FW, Oltz EM, Young F, Gorman J, Taccioli G, Chen J.
Immunol Today 1992-08-01
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A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible.

Authors: Authors: Oltz EM, Yancopoulos GD, Morrow MA, Rolink A, Lee G, Wong F, Kaplan K, Gillis S, Melchers F, Alt FW.
EMBO J 1992-07-01
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T helper cell membranes promote IL-4-independent expression of germ-line C gamma 1 transcripts in B cells.

Authors: Authors: Schultz CL, Rothman P, Kühn R, Kehry M, Müller W, Rajewsky K, Alt F, Coffman RL.
J Immunol 1992-07-01
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Surface IgM mediated regulation of RAG gene expression in E mu-N-myc B cell lines.

Authors: Authors: Ma A, Fisher P, Dildrop R, Oltz E, Rathbun G, Achacoso P, Stall A, Alt FW.
EMBO J 1992-07-01
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Functional homology between N-myc and c-myc in murine plasmacytomagenesis: plasmacytoma development in N-myc transgenic mice.

Authors: Authors: Wang Y, Sugiyama H, Axelson H, Panda CK, Babonits M, Ma A, Steinberg JM, Alt FW, Klein G, Wiener F.
Oncogene 1992-06-01
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Endoplasmic reticulum resident protein of 90 kilodaltons associates with the T- and B-cell antigen receptors and major histocompatibility complex antigens during their assembly.

Authors: Authors: Hochstenbach F, David V, Watkins S, Brenner MB.
Proc Natl Acad Sci U S A 1992-05-15
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