Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

VDJ recombination.

Authors: Authors: Alt FW, Oltz EM, Young F, Gorman J, Taccioli G, Chen J.
Immunol Today 1992-08-01
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A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible.

Authors: Authors: Oltz EM, Yancopoulos GD, Morrow MA, Rolink A, Lee G, Wong F, Kaplan K, Gillis S, Melchers F, Alt FW.
EMBO J 1992-07-01
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T helper cell membranes promote IL-4-independent expression of germ-line C gamma 1 transcripts in B cells.

Authors: Authors: Schultz CL, Rothman P, Kühn R, Kehry M, Müller W, Rajewsky K, Alt F, Coffman RL.
J Immunol 1992-07-01
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Surface IgM mediated regulation of RAG gene expression in E mu-N-myc B cell lines.

Authors: Authors: Ma A, Fisher P, Dildrop R, Oltz E, Rathbun G, Achacoso P, Stall A, Alt FW.
EMBO J 1992-07-01
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Functional homology between N-myc and c-myc in murine plasmacytomagenesis: plasmacytoma development in N-myc transgenic mice.

Authors: Authors: Wang Y, Sugiyama H, Axelson H, Panda CK, Babonits M, Ma A, Steinberg JM, Alt FW, Klein G, Wiener F.
Oncogene 1992-06-01
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Endoplasmic reticulum resident protein of 90 kilodaltons associates with the T- and B-cell antigen receptors and major histocompatibility complex antigens during their assembly.

Authors: Authors: Hochstenbach F, David V, Watkins S, Brenner MB.
Proc Natl Acad Sci U S A 1992-05-15
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Function and control of recombination-activating gene activity.

Authors: Authors: Alt FW, Rathbun G, Oltz E, Taccioli G, Shinkai Y.
Ann N Y Acad Sci 1992-05-04
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Transcriptional down-regulation of N-myc expression during B-cell development.

Authors: Authors: Smith RK, Zimmerman K, Yancopoulos GD, Ma A, Alt FW.
Mol Cell Biol 1992-04-01
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A family of beta 7 integrins on human mucosal lymphocytes.

Authors: Authors: Parker CM, Cepek KL, Russell GJ, Shaw SK, Posnett DN, Schwarting R, Brenner MB.
Proc Natl Acad Sci U S A 1992-03-01
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High frequency of myelomonocytic tumors in aging E mu L-myc transgenic mice.

Authors: Authors: Möröy T, Fisher PE, Lee G, Achacoso P, Wiener F, Alt FW.
J Exp Med 1992-02-01
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