Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Interleukin-7 induces N-myc and c-myc expression in normal precursor B lymphocytes.

Authors: Authors: Morrow MA, Lee G, Gillis S, Yancopoulos GD, Alt FW.
Genes Dev 1992-01-01
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Activities involved in V(D)J recombination.

Authors: Authors: Taccioli GE, Rathbun G, Shinkai Y, Oltz EM, Cheng H, Whitmore G, Stamato T, Jeggo P, Alt FW.
Curr Top Microbiol Immunol 1992-01-01
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Oligoclonality of human intestinal intraepithelial T cells.

Authors: Authors: Van Kerckhove C, Russell GJ, Deusch K, Reich K, Bhan AK, DerSimonian H, Brenner MB.
J Exp Med 1992-01-01
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Functionally distinct subsets of human gamma/delta T cells.

Authors: Authors: Morita CT, Verma S, Aparicio P, Martinez C, Spits H, Brenner MB.
Eur J Immunol 1991-12-01
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A predominance of the T cell receptor V gamma 2/V delta 2 subset in human mycobacteria-responsive T cells suggests germline gene encoded recognition.

Authors: Authors: Panchamoorthy G, McLean J, Modlin RL, Morita CT, Ishikawa S, Brenner MB, Band H.
J Immunol 1991-11-15
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"Increased frequency of T cell receptor V alpha 12.1 expression on CD8+ T cells: evidence that V alpha participates in shaping the peripheral T cell repertoire".

Authors: Authors: DerSimonian H, Band H, Brenner MB.
J Exp Med 1991-11-01
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E mu N- and E mu L-myc cooperate with E mu pim-1 to generate lymphoid tumors at high frequency in double-transgenic mice.

Authors: Authors: Möröy T, Verbeek S, Ma A, Achacoso P, Berns A, Alt F.
Oncogene 1991-11-01
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Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line epsilon transcripts.

Authors: Authors: Rothman P, Li SC, Gorham B, Glimcher L, Alt F, Boothby M.
Mol Cell Biol 1991-11-01
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Analysis of clones derived from human CD7+CD4-CD8-CD3- thymocytes.

Authors: Authors: Denning SM, Jones DM, Ware RE, Weinhold KJ, Brenner MB, Haynes BF.
Int Immunol 1991-10-01
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Diversity of immunoglobulin heavy chain gene segment rearrangement in B lymphoblastoid cell lines from X-linked agammaglobulinemia patients.

Authors: Authors: Timmers E, Kenter M, Thompson A, Kraakman ME, Berman JE, Alt FW, Schuurman RK.
Eur J Immunol 1991-10-01
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