Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Function and control of recombination-activating gene activity.

Authors: Authors: Alt FW, Rathbun G, Oltz E, Taccioli G, Shinkai Y.
Ann N Y Acad Sci 1992-05-04
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Transcriptional down-regulation of N-myc expression during B-cell development.

Authors: Authors: Smith RK, Zimmerman K, Yancopoulos GD, Ma A, Alt FW.
Mol Cell Biol 1992-04-01
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A family of beta 7 integrins on human mucosal lymphocytes.

Authors: Authors: Parker CM, Cepek KL, Russell GJ, Shaw SK, Posnett DN, Schwarting R, Brenner MB.
Proc Natl Acad Sci U S A 1992-03-01
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High frequency of myelomonocytic tumors in aging E mu L-myc transgenic mice.

Authors: Authors: Möröy T, Fisher PE, Lee G, Achacoso P, Wiener F, Alt FW.
J Exp Med 1992-02-01
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Oligoclonality of human intestinal intraepithelial T cells.

Authors: Authors: Van Kerckhove C, Russell GJ, Deusch K, Reich K, Bhan AK, DerSimonian H, Brenner MB.
J Exp Med 1992-01-01
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Interleukin-7 induces N-myc and c-myc expression in normal precursor B lymphocytes.

Authors: Authors: Morrow MA, Lee G, Gillis S, Yancopoulos GD, Alt FW.
Genes Dev 1992-01-01
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Activities involved in V(D)J recombination.

Authors: Authors: Taccioli GE, Rathbun G, Shinkai Y, Oltz EM, Cheng H, Whitmore G, Stamato T, Jeggo P, Alt FW.
Curr Top Microbiol Immunol 1992-01-01
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Functionally distinct subsets of human gamma/delta T cells.

Authors: Authors: Morita CT, Verma S, Aparicio P, Martinez C, Spits H, Brenner MB.
Eur J Immunol 1991-12-01
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A predominance of the T cell receptor V gamma 2/V delta 2 subset in human mycobacteria-responsive T cells suggests germline gene encoded recognition.

Authors: Authors: Panchamoorthy G, McLean J, Modlin RL, Morita CT, Ishikawa S, Brenner MB, Band H.
J Immunol 1991-11-15
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E mu N- and E mu L-myc cooperate with E mu pim-1 to generate lymphoid tumors at high frequency in double-transgenic mice.

Authors: Authors: Möröy T, Verbeek S, Ma A, Achacoso P, Berns A, Alt F.
Oncogene 1991-11-01
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