Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

E mu N- and E mu L-myc cooperate with E mu pim-1 to generate lymphoid tumors at high frequency in double-transgenic mice.

Authors: Authors: Möröy T, Verbeek S, Ma A, Achacoso P, Berns A, Alt F.
Oncogene 1991-11-01
View full abstract on Pubmed

Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line epsilon transcripts.

Authors: Authors: Rothman P, Li SC, Gorham B, Glimcher L, Alt F, Boothby M.
Mol Cell Biol 1991-11-01
View full abstract on Pubmed

Analysis of clones derived from human CD7+CD4-CD8-CD3- thymocytes.

Authors: Authors: Denning SM, Jones DM, Ware RE, Weinhold KJ, Brenner MB, Haynes BF.
Int Immunol 1991-10-01
View full abstract on Pubmed

Diversity of immunoglobulin heavy chain gene segment rearrangement in B lymphoblastoid cell lines from X-linked agammaglobulinemia patients.

Authors: Authors: Timmers E, Kenter M, Thompson A, Kraakman ME, Berman JE, Alt FW, Schuurman RK.
Eur J Immunol 1991-10-01
View full abstract on Pubmed

Increased frequency of T cell receptor V alpha 12.1 expression on CD8+ T cells: evidence that V alpha participates in shaping the peripheral T cell repertoire.

Authors: Authors: DerSimonian H, Band H, Brenner MB.
J Exp Med 1991-09-01
View full abstract on Pubmed

Complexity of the immunoglobulin light chain V kappa 1 gene family in the New Zealand black mouse.

Authors: Authors: Bailey NC, Kasturi KN, Blackwell TK, Alt FW, Bona CA.
Int Immunol 1991-08-01
View full abstract on Pubmed

Structure and expression of human germline VH transcripts.

Authors: Authors: Berman JE, Humphries CG, Barth J, Alt FW, Tucker PW.
J Exp Med 1991-06-01
View full abstract on Pubmed

VH gene usage in humans: biased usage of the VH6 gene in immature B lymphoid cells.

Authors: Authors: Berman JE, Nickerson KG, Pollock RR, Barth JE, Schuurman RK, Knowles DM, Chess L, Alt FW.
Eur J Immunol 1991-05-01
View full abstract on Pubmed

Predominant T cell receptor V gene usage in patients with abnormal clones of B cells.

Authors: Authors: Janson CH, Grunewald J, Osterborg A, DerSimonian H, Brenner MB, Mellstedt H, Wigzell H.
Blood 1991-04-15
View full abstract on Pubmed

Correlation between the occurrence of lupus nephritis, anti-erythrocyte autoantibodies and V kappa haplotype in NZB x 129/J and NZB x SM/J recombinant inbred murine strains.

Authors: Authors: Bailey NC, Bona A, Dikman S, Bonilla F, Alt FW, Bona C.
Eur J Immunol 1991-04-01
View full abstract on Pubmed