Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Antigens and antigen-presenting molecules for gamma delta T cells.

Authors: Authors: Band H, Porcelli SA, Panchamoorthy G, McLean J, Morita CT, Ishikawa S, Modlin RL, Brenner MB.
Curr Top Microbiol Immunol 1991-01-01
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Control of immunoglobulin heavy chain constant region gene expression.

Authors: Authors: Li SC, Rothman P, Boothby M, Ferrier P, Glimcher L, Alt FW.
Adv Exp Med Biol 1991-01-01
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Gamma delta T cells in leprosy lesions.

Authors: Authors: Uyemura K, Band H, Ohmen J, Brenner MB, Rea TH, Modlin RL.
Curr Top Microbiol Immunol 1991-01-01
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Mechanism of endogenous myc gene down-regulation in E mu-N-myc tumors.

Authors: Authors: Ma A, Smith RK, Tesfaye A, Achacoso P, Dildrop R, Rosenberg N, Alt FW.
Mol Cell Biol 1991-01-01
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Molecular cloning of a human immunoglobulin heavy chain variable (vh) region with anti-myelin-associated glycoprotein activity.

Authors: Authors: Desai R, Spatz L, Matsuda T, Ilyas AA, Berman JE, Alt FW, Kabat EA, Latov N.
J Neuroimmunol 1990-12-01
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IgH enhancer deregulated expression of L-myc: abnormal T lymphocyte development and T cell lymphomagenesis.

Authors: Authors: Möröy T, Fisher P, Guidos C, Ma A, Zimmerman K, Tesfaye A, DePinho R, Weissman I, Alt FW.
EMBO J 1990-11-01
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Recognition of mycobacterial antigens by gamma delta T cells.

Authors: Authors: Band H, Panchamoorthy G, Mclean J, Morita CT, Ishikawa S, Modlin R, Brenner MB.
Res Immunol 1990-09-01
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Normal recombination substrate VH to DJH rearrangements in pre-B cell lines from scid mice.

Authors: Authors: Ferrier P, Covey LR, Li SC, Suh H, Malynn BA, Blackwell TK, Morrow MA, Alt FW.
J Exp Med 1990-06-01
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Differential regulation of the N-myc gene in transfected cells and transgenic mice.

Authors: Authors: Zimmerman K, Legouy E, Stewart V, Depinho R, Alt FW.
Mol Cell Biol 1990-05-01
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Evidence for extrathymic changes in the T cell receptor gamma/delta repertoire.

Authors: Authors: Parker CM, Groh V, Band H, Porcelli SA, Morita C, Fabbi M, Glass D, Strominger JL, Brenner MB.
J Exp Med 1990-05-01
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