Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

VH gene usage in humans: biased usage of the VH6 gene in immature B lymphoid cells.

Authors: Authors: Berman JE, Nickerson KG, Pollock RR, Barth JE, Schuurman RK, Knowles DM, Chess L, Alt FW.
Eur J Immunol 1991-05-01
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Predominant T cell receptor V gene usage in patients with abnormal clones of B cells.

Authors: Authors: Janson CH, Grunewald J, Osterborg A, DerSimonian H, Brenner MB, Mellstedt H, Wigzell H.
Blood 1991-04-15
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Correlation between the occurrence of lupus nephritis, anti-erythrocyte autoantibodies and V kappa haplotype in NZB x 129/J and NZB x SM/J recombinant inbred murine strains.

Authors: Authors: Bailey NC, Bona A, Dikman S, Bonilla F, Alt FW, Bona C.
Eur J Immunol 1991-04-01
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Biology of the human gamma delta T-cell receptor.

Authors: Authors: Porcelli S, Brenner MB, Band H.
Immunol Rev 1991-04-01
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Structure and expression of canary myc family genes.

Authors: Authors: Collum RG, Clayton DF, Alt FW.
Mol Cell Biol 1991-03-01
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DNA recombination in the brain?

Authors: Authors: Alt FW, Rathbun G, Yancopoulos GD.
Curr Biol 1991-02-01
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Antigens and antigen-presenting molecules for gamma delta T cells.

Authors: Authors: Band H, Porcelli SA, Panchamoorthy G, McLean J, Morita CT, Ishikawa S, Modlin RL, Brenner MB.
Curr Top Microbiol Immunol 1991-01-01
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Control of immunoglobulin heavy chain constant region gene expression.

Authors: Authors: Li SC, Rothman P, Boothby M, Ferrier P, Glimcher L, Alt FW.
Adv Exp Med Biol 1991-01-01
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Gamma delta T cells in leprosy lesions.

Authors: Authors: Uyemura K, Band H, Ohmen J, Brenner MB, Rea TH, Modlin RL.
Curr Top Microbiol Immunol 1991-01-01
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Mechanism of endogenous myc gene down-regulation in E mu-N-myc tumors.

Authors: Authors: Ma A, Smith RK, Tesfaye A, Achacoso P, Dildrop R, Rosenberg N, Alt FW.
Mol Cell Biol 1991-01-01
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