Frederick Alt, Ph.D.
Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.
Cloning and sequence analysis of the VH and VL regions of an anti-myelin/DNA antibody from a patient with peripheral neuropathy and chronic lymphocytic leukemia.
Authors: Authors: Spatz LA, Wong KK, Williams M, Desai R, Golier J, Berman JE, Alt FW, Latov N.
J Immunol
View full abstract on Pubmed
J Immunol
View full abstract on Pubmed
High-frequency disruption of the N-myc gene in embryonic stem and pre-B cell lines by homologous recombination.
Authors: Authors: Charron J, Malynn BA, Robertson EJ, Goff SP, Alt FW.
Mol Cell Biol
View full abstract on Pubmed
Mol Cell Biol
View full abstract on Pubmed
Structure and expression of germ line immunoglobulin heavy-chain epsilon transcripts: interleukin-4 plus lipopolysaccharide-directed switching to C epsilon.
Authors: Authors: Rothman P, Chen YY, Lutzker S, Li SC, Stewart V, Coffman R, Alt FW.
Mol Cell Biol
View full abstract on Pubmed
Mol Cell Biol
View full abstract on Pubmed
A novel fluorescence-based system for assaying and separating live cells according to VDJ recombinase activity.
Authors: Authors: Yancopoulos GD, Nolan GP, Pollock R, Prockop S, Li SC, Herzenberg LA, Alt FW.
Mol Cell Biol
View full abstract on Pubmed
Mol Cell Biol
View full abstract on Pubmed
Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice.
Authors: Authors: Malynn BA, Yancopoulos GD, Barth JE, Bona CA, Alt FW.
J Exp Med
View full abstract on Pubmed
J Exp Med
View full abstract on Pubmed
Human T cell receptor-gamma and -delta chain pairing analyzed by transfection of a T cell receptor-delta negative mutant cell line.
Authors: Authors: Solomon KR, Krangel MS, McLean J, Brenner MB, Band H.
J Immunol
View full abstract on Pubmed
J Immunol
View full abstract on Pubmed
Are myc proteins transcription factors?
Human heavy chain variable region gene diversity, organization, and expression.
Structure and expression of germline immunoglobulin gamma 3 heavy chain gene transcripts: implications for mitogen and lymphokine directed class-switching.
Authors: Authors: Rothman P, Lutzker S, Gorham B, Stewart V, Coffman R, Alt FW.
Int Immunol
View full abstract on Pubmed
Int Immunol
View full abstract on Pubmed
VH to VHDJH rearrangement is mediated by the internal VH heptamer.