Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Cloning and sequence analysis of the VH and VL regions of an anti-myelin/DNA antibody from a patient with peripheral neuropathy and chronic lymphocytic leukemia.

Authors: Authors: Spatz LA, Wong KK, Williams M, Desai R, Golier J, Berman JE, Alt FW, Latov N.
J Immunol 1990-04-01
View full abstract on Pubmed

Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice.

Authors: Authors: Malynn BA, Yancopoulos GD, Barth JE, Bona CA, Alt FW.
J Exp Med 1990-03-01
View full abstract on Pubmed

Human T cell receptor-gamma and -delta chain pairing analyzed by transfection of a T cell receptor-delta negative mutant cell line.

Authors: Authors: Solomon KR, Krangel MS, McLean J, Brenner MB, Band H.
J Immunol 1990-03-01
View full abstract on Pubmed

Are myc proteins transcription factors?

Authors: Authors: Collum RG, Alt FW.
Cancer Cells 1990-03-01
View full abstract on Pubmed

VH to VHDJH rearrangement is mediated by the internal VH heptamer.

Authors: Authors: Covey LR, Ferrier P, Alt FW.
Int Immunol 1990-01-01
View full abstract on Pubmed

Molecular cloning of a human immunoglobulin heavy chain variable (VH) region with anti-myelin-associated glycoprotein activity.

Authors: Authors: Desai R, Spatz L, Matsuda T, Ilyas AA, Berman JE, Alt FW, Kabat EA, Latov N.
J Neuroimmunol 1990-01-01
View full abstract on Pubmed

Newly identified gamma delta and beta delta T-cell receptors.

Authors: Authors: Hochstenbach F, Brenner MB.
J Clin Immunol 1990-01-01
View full abstract on Pubmed

Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.

Authors: Authors: Ferrier P, Krippl B, Blackwell TK, Furley AJ, Suh H, Winoto A, Cook WD, Hood L, Costantini F, Alt FW.
EMBO J 1990-01-01
View full abstract on Pubmed

Expression and function of myc family genes.

Authors: Authors: Zimmerman K, Alt FW.
Crit Rev Oncog 1990-01-01
View full abstract on Pubmed

Human heavy chain variable region gene diversity, organization, and expression.

Authors: Authors: Berman JE, Alt FW.
Int Rev Immunol 1990-01-01
View full abstract on Pubmed