Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Molecular cloning of a human immunoglobulin heavy chain variable (VH) region with anti-myelin-associated glycoprotein activity.

Authors: Authors: Desai R, Spatz L, Matsuda T, Ilyas AA, Berman JE, Alt FW, Kabat EA, Latov N.
J Neuroimmunol 1990-01-01
View full abstract on Pubmed

Newly identified gamma delta and beta delta T-cell receptors.

Authors: Authors: Hochstenbach F, Brenner MB.
J Clin Immunol 1990-01-01
View full abstract on Pubmed

Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.

Authors: Authors: Ferrier P, Krippl B, Blackwell TK, Furley AJ, Suh H, Winoto A, Cook WD, Hood L, Costantini F, Alt FW.
EMBO J 1990-01-01
View full abstract on Pubmed

Expression and function of myc family genes.

Authors: Authors: Zimmerman K, Alt FW.
Crit Rev Oncog 1990-01-01
View full abstract on Pubmed

Immunology: making antigen-receptor genes.

Authors: Authors: Rathbun G, Alt FW, Yancopoulos GD.
Nature 1989-12-21
View full abstract on Pubmed

Recognition of cluster of differentiation 1 antigens by human CD4-CD8-cytolytic T lymphocytes.

Authors: Authors: Porcelli S, Brenner MB, Greenstein JL, Balk SP, Terhorst C, Bleicher PA.
Nature 1989-10-05
View full abstract on Pubmed

Autoantibodies encoded by the most Jh-proximal human immunoglobulin heavy chain variable region gene.

Authors: Authors: Logtenberg T, Young FM, Van Es JH, Gmelig-Meyling FH, Alt FW.
J Exp Med 1989-10-01
View full abstract on Pubmed

Evolution of immunoglobulin genes: VH families in the amphibian Xenopus.

Authors: Authors: Hsu E, Schwager J, Alt FW.
Proc Natl Acad Sci U S A 1989-10-01
View full abstract on Pubmed

The molecular events in heavy chain class-switching.

Authors: Authors: Rothman P, Li SC, Alt FW.
Semin Immunol 1989-09-01
View full abstract on Pubmed

A novel monoclonal antibody, 1B3.1, binds to a new epitope of the VLA-1 molecule.

Authors: Authors: Bank I, Hemler M, Brenner MB, Cohen D, Levy V, Belko J, Crouse C, Chess L.
Cell Immunol 1989-09-01
View full abstract on Pubmed