Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

VH to VHDJH rearrangement is mediated by the internal VH heptamer.

Authors: Authors: Covey LR, Ferrier P, Alt FW.
Int Immunol 1990-01-01
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Immunology: making antigen-receptor genes.

Authors: Authors: Rathbun G, Alt FW, Yancopoulos GD.
Nature 1989-12-21
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Recognition of cluster of differentiation 1 antigens by human CD4-CD8-cytolytic T lymphocytes.

Authors: Authors: Porcelli S, Brenner MB, Greenstein JL, Balk SP, Terhorst C, Bleicher PA.
Nature 1989-10-05
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Evolution of immunoglobulin genes: VH families in the amphibian Xenopus.

Authors: Authors: Hsu E, Schwager J, Alt FW.
Proc Natl Acad Sci U S A 1989-10-01
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Autoantibodies encoded by the most Jh-proximal human immunoglobulin heavy chain variable region gene.

Authors: Authors: Logtenberg T, Young FM, Van Es JH, Gmelig-Meyling FH, Alt FW.
J Exp Med 1989-10-01
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A novel monoclonal antibody, 1B3.1, binds to a new epitope of the VLA-1 molecule.

Authors: Authors: Bank I, Hemler M, Brenner MB, Cohen D, Levy V, Belko J, Crouse C, Chess L.
Cell Immunol 1989-09-01
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The molecular events in heavy chain class-switching.

Authors: Authors: Rothman P, Li SC, Alt FW.
Semin Immunol 1989-09-01
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T-cell receptor delta-chain can substitute for alpha to form a beta delta heterodimer.

Authors: Authors: Hochstenbach F, Brenner MB.
Nature 1989-08-17
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Molecular characterization of the lymphoid V(D)J recombination activity.

Authors: Authors: Blackwell TK, Alt FW.
J Biol Chem 1989-06-25
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Lymphocytes bearing antigen-specific gamma delta T-cell receptors accumulate in human infectious disease lesions.

Authors: Authors: Modlin RL, Pirmez C, Hofman FM, Torigian V, Uyemura K, Rea TH, Bloom BR, Brenner MB.
Nature 1989-06-15
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