Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

T-cell receptor delta-chain can substitute for alpha to form a beta delta heterodimer.
Authors: Authors: Hochstenbach F, Brenner MB.
Nature
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Molecular characterization of the lymphoid V(D)J recombination activity.
Authors: Authors: Blackwell TK, Alt FW.
J Biol Chem
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Lymphocytes bearing antigen-specific gamma delta T-cell receptors accumulate in human infectious disease lesions.
Authors: Authors: Modlin RL, Pirmez C, Hofman FM, Torigian V, Uyemura K, Rea TH, Bloom BR, Brenner MB.
Nature
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Frequency of VH-gene utilization in human EBV-transformed B-cell lines: the most JH-proximal VH segment encodes autoantibodies.
Authors: Authors: Logtenberg T, Young FM, van Es J, Gmelig-Meyling FH, Berman JE, Alt FW.
J Autoimmun
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Expression of human T cell receptor-gamma delta structural forms.
Authors: Authors: Band H, Hochstenbach F, Parker CM, McLean J, Krangel MS, Brenner MB.
J Immunol
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Human lymphocytes bearing T cell receptor gamma/delta are phenotypically diverse and evenly distributed throughout the lymphoid system.
Authors: Authors: Groh V, Porcelli S, Fabbi M, Lanier LL, Picker LJ, Anderson T, Warnke RA, Bhan AK, Strominger JL, Brenner MB.
J Exp Med
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Early human IgH gene assembly in Epstein-Barr virus-transformed fetal B cell lines. Preferential utilization of the most JH-proximal D segment (DQ52) and two unusual VH-related rearrangements.
Authors: Authors: Nickerson KG, Berman J, Glickman E, Chess L, Alt FW.
J Exp Med
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IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c-myc expression.
Authors: Authors: Dildrop R, Ma A, Zimmerman K, Hsu E, Tesfaye A, DePinho R, Alt FW.
EMBO J
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Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins.
Authors: Authors: Blackwell TK, Malynn BA, Pollock RR, Ferrier P, Covey LR, Fulop GM, Phillips RA, Yancopoulos GD, Alt FW.
EMBO J
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Immunoglobulin VH gene expression in human B cell lines and tumors: biased VH gene expression in chronic lymphocytic leukemia.
Authors: Authors: Logtenberg T, Schutte ME, Inghirami G, Berman JE, Gmelig-Meyling FH, Insel RA, Knowles DM, Alt FW.
Int Immunol
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