Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Characteristics of 27 human T-cell leukemia cell lines with/without T-cell receptors of T3-Ti alpha beta or T3-Ti gamma delta complex.

Authors: Authors: Minowada J, Kohno K, Matsuo Y, Drexler HG, Ohnuma T, Tax WJ, Brenner MB.
Haematol Blood Transfus 1989-01-01
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Mechanism and developmental program of immunoglobulin gene rearrangement in mammals.

Authors: Authors: Blackwell TK, Alt FW.
Annu Rev Genet 1989-01-01
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Chromosomal location of N-myc and L-myc genes in the mouse.

Authors: Authors: Campbell GR, Zimmerman K, Blank RD, Alt FW, D'Eustachio P.
Oncogene Res 1989-01-01
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T cell receptor DJ but not VDJ rearrangement within a recombination substrate introduced into a pre-B cell line.

Authors: Authors: Ferrier P, Covey LR, Suh H, Winoto A, Hood L, Alt FW.
Int Immunol 1989-01-01
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Immunoglobulin VH gene expression in human B cell lines and tumors: biased VH gene expression in chronic lymphocytic leukemia.

Authors: Authors: Logtenberg T, Schutte ME, Inghirami G, Berman JE, Gmelig-Meyling FH, Insel RA, Knowles DM, Alt FW.
Int Immunol 1989-01-01
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Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells.

Authors: Authors: Rothman P, Lutzker S, Cook W, Coffman R, Alt FW.
J Exp Med 1988-12-01
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Gene expression in renal growth and regrowth.

Authors: Authors: Sawczuk IS, Olsson CA, Buttyan R, Nguyen-Huu MC, Zimmerman KA, Alt FW, Zakeri Z, Wolgemuth D, Reitelman C.
J Urol 1988-11-01
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Structure of the gamma/delta T cell receptor of a human thymocyte clone.

Authors: Authors: Okada A, Bank I, Rogozinski L, Takihara Y, Mak TW, Chess L, Alt FW.
J Exp Med 1988-10-01
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N-myc proto-oncogene expression during organogenesis in the developing mouse as revealed by in situ hybridization.

Authors: Authors: Mugrauer G, Alt FW, Ekblom P.
J Cell Biol 1988-10-01
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Reconstruction of an immune system.

Authors: Authors: Yancopoulos GD, Alt FW.
Science 1988-09-23
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