Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Early human IgH gene assembly in Epstein-Barr virus-transformed fetal B cell lines. Preferential utilization of the most JH-proximal D segment (DQ52) and two unusual VH-related rearrangements.

Authors: Authors: Nickerson KG, Berman J, Glickman E, Chess L, Alt FW.
J Exp Med 1989-04-01
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IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c-myc expression.

Authors: Authors: Dildrop R, Ma A, Zimmerman K, Hsu E, Tesfaye A, DePinho R, Alt FW.
EMBO J 1989-04-01
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Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins.

Authors: Authors: Blackwell TK, Malynn BA, Pollock RR, Ferrier P, Covey LR, Fulop GM, Phillips RA, Yancopoulos GD, Alt FW.
EMBO J 1989-03-01
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Chromosomal location of N-myc and L-myc genes in the mouse.

Authors: Authors: Campbell GR, Zimmerman K, Blank RD, Alt FW, D'Eustachio P.
Oncogene Res 1989-01-01
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T cell receptor DJ but not VDJ rearrangement within a recombination substrate introduced into a pre-B cell line.

Authors: Authors: Ferrier P, Covey LR, Suh H, Winoto A, Hood L, Alt FW.
Int Immunol 1989-01-01
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Immunoglobulin VH gene expression in human B cell lines and tumors: biased VH gene expression in chronic lymphocytic leukemia.

Authors: Authors: Logtenberg T, Schutte ME, Inghirami G, Berman JE, Gmelig-Meyling FH, Insel RA, Knowles DM, Alt FW.
Int Immunol 1989-01-01
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Human T cell receptor gamma delta structure.

Authors: Authors: Brenner MB, Hochstenbach F, Band H, Parker C, McLean J, Hata S, Krangel M.
Adv Exp Med Biol 1989-01-01
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Characteristics of 27 human T-cell leukemia cell lines with/without T-cell receptors of T3-Ti alpha beta or T3-Ti gamma delta complex.

Authors: Authors: Minowada J, Kohno K, Matsuo Y, Drexler HG, Ohnuma T, Tax WJ, Brenner MB.
Haematol Blood Transfus 1989-01-01
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Mechanism and developmental program of immunoglobulin gene rearrangement in mammals.

Authors: Authors: Blackwell TK, Alt FW.
Annu Rev Genet 1989-01-01
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Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells.

Authors: Authors: Rothman P, Lutzker S, Cook W, Coffman R, Alt FW.
J Exp Med 1988-12-01
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