Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Expression of T cell receptor delta chains in benign and malignant T lineage lymphoproliferations.

Authors: Authors: Picker LJ, Brenner MB, Michie S, Warnke RA.
Am J Pathol 1988-09-01
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The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism.

Authors: Authors: Malynn BA, Blackwell TK, Fulop GM, Rathbun GA, Furley AJ, Ferrier P, Heinke LB, Phillips RA, Yancopoulos GD, Alt FW.
Cell 1988-08-12
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T cells expressing gamma delta chain receptors in rheumatoid arthritis.

Authors: Authors: Brennan FM, Londei M, Jackson AM, Hercend T, Brenner MB, Maini RN, Feldmann M.
J Autoimmun 1988-08-01
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Developmentally regulated and strain-specific expression of murine VH gene families.

Authors: Authors: Yancopoulos GD, Malynn BA, Alt FW.
J Exp Med 1988-07-01
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Extensive junctional diversity of rearranged human T cell receptor delta genes.

Authors: Authors: Hata S, Satyanarayana K, Devlin P, Band H, McLean J, Strominger JL, Brenner MB, Krangel MS.
Science 1988-06-10
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N-myc oncogene expression in histopathologically unrelated bilateral pediatric renal tumors.

Authors: Authors: Nisen PD, Rich MA, Gloster E, Valderrama E, Saric O, Shende A, Lanzkowsky P, Alt FW.
Cancer 1988-05-01
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Mitogen- and IL-4-regulated expression of germ-line Ig gamma 2b transcripts: evidence for directed heavy chain class switching.

Authors: Authors: Lutzker S, Rothman P, Pollock R, Coffman R, Alt FW.
Cell 1988-04-22
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Structure and expression of germ line immunoglobulin gamma 2b transcripts.

Authors: Authors: Lutzker S, Alt FW.
Mol Cell Biol 1988-04-01
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Sequence and organization of the human T cell delta chain gene.

Authors: Authors: Takihara Y, Champagne E, Griesser H, Kimura N, Tkachuk D, Reimann J, Okada A, Alt FW, Chess L, Minden M, et al.
Eur J Immunol 1988-02-01
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The gamma delta T cell receptor.

Authors: Authors: Brenner MB, Strominger JL, Krangel MS.
Adv Immunol 1988-01-01
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