Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Mitogen- and IL-4-regulated expression of germ-line Ig gamma 2b transcripts: evidence for directed heavy chain class switching.

Authors: Authors: Lutzker S, Rothman P, Pollock R, Coffman R, Alt FW.
Cell 1988-04-22
View full abstract on Pubmed

Structure and expression of germ line immunoglobulin gamma 2b transcripts.

Authors: Authors: Lutzker S, Alt FW.
Mol Cell Biol 1988-04-01
View full abstract on Pubmed

Sequence and organization of the human T cell delta chain gene.

Authors: Authors: Takihara Y, Champagne E, Griesser H, Kimura N, Tkachuk D, Reimann J, Okada A, Alt FW, Chess L, Minden M, et al.
Eur J Immunol 1988-02-01
View full abstract on Pubmed

Differential expression of myc-family genes during development: normal and deregulated N-myc expression in transgenic mice.

Authors: Authors: Dildrop R, Zimmerman K, DePinho RA, Yancopoulos GD, Tesfaye A, Alt FW.
Curr Top Microbiol Immunol 1988-01-01
View full abstract on Pubmed

The gamma delta T cell receptor.

Authors: Authors: Brenner MB, Strominger JL, Krangel MS.
Adv Immunol 1988-01-01
View full abstract on Pubmed

Control of recombination events during lymphocyte differentiation. Heavy chain variable region gene assembly and heavy chain class switching.

Authors: Authors: Alt FW, Ferrier P, Malynn B, Lutzker S, Rothman P, Berman J, Blackwell K, Mellis S, Pollock R, Furley A, et al.
Ann N Y Acad Sci 1988-01-01
View full abstract on Pubmed

Discordant expression of CD3 and T-cell receptor beta-chain antigens in T-lineage lymphomas.

Authors: Authors: Picker LJ, Brenner MB, Weiss LM, Smith SD, Warnke RA.
Am J Pathol 1987-12-01
View full abstract on Pubmed

Structure and expression of the human and mouse T4 genes.

Authors: Authors: Maddon PJ, Molineaux SM, Maddon DE, Zimmerman KA, Godfrey M, Alt FW, Chess L, Axel R.
Proc Natl Acad Sci U S A 1987-12-01
View full abstract on Pubmed

The human myc gene family: structure and activity of L-myc and an L-myc pseudogene.

Authors: Authors: DePinho RA, Hatton KS, Tesfaye A, Yancopoulos GD, Alt FW.
Genes Dev 1987-12-01
View full abstract on Pubmed

Development of the primary antibody repertoire.

Authors: Authors: Alt FW, Blackwell TK, Yancopoulos GD.
Science 1987-11-20
View full abstract on Pubmed