Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

The gamma delta T cell receptor.

Authors: Authors: Brenner MB, Strominger JL, Krangel MS.
Adv Immunol 1988-01-01
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Control of recombination events during lymphocyte differentiation. Heavy chain variable region gene assembly and heavy chain class switching.

Authors: Authors: Alt FW, Ferrier P, Malynn B, Lutzker S, Rothman P, Berman J, Blackwell K, Mellis S, Pollock R, Furley A, et al.
Ann N Y Acad Sci 1988-01-01
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Discordant expression of CD3 and T-cell receptor beta-chain antigens in T-lineage lymphomas.

Authors: Authors: Picker LJ, Brenner MB, Weiss LM, Smith SD, Warnke RA.
Am J Pathol 1987-12-01
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Structure and expression of the human and mouse T4 genes.

Authors: Authors: Maddon PJ, Molineaux SM, Maddon DE, Zimmerman KA, Godfrey M, Alt FW, Chess L, Axel R.
Proc Natl Acad Sci U S A 1987-12-01
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The human myc gene family: structure and activity of L-myc and an L-myc pseudogene.

Authors: Authors: DePinho RA, Hatton KS, Tesfaye A, Yancopoulos GD, Alt FW.
Genes Dev 1987-12-01
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Development of the primary antibody repertoire.

Authors: Authors: Alt FW, Blackwell TK, Yancopoulos GD.
Science 1987-11-20
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Activation of V kappa gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains.

Authors: Authors: Reth M, Petrac E, Wiese P, Lobel L, Alt FW.
EMBO J 1987-11-01
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Structure and expression of the murine L-myc gene.

Authors: Authors: Legouy E, DePinho R, Zimmerman K, Collum R, Yancopoulos G, Mitsock L, Kriz R, Alt FW.
EMBO J 1987-11-01
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Identification of putative human T cell receptor delta complementary DNA clones.

Authors: Authors: Hata S, Brenner MB, Krangel MS.
Science 1987-10-30
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Immunochemical proof that a novel rearranging gene encodes the T cell receptor delta subunit.

Authors: Authors: Band H, Hochstenbach F, McLean J, Hata S, Krangel MS, Brenner MB.
Science 1987-10-30
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