Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

T-cell receptors of human suppressor cells.

Authors: Authors: Modlin RL, Brenner MB, Krangel MS, Duby AD, Bloom BR.
Nature 1987-10-08
View full abstract on Pubmed

Structurally divergent human T cell receptor gamma proteins encoded by distinct C gamma genes.

Authors: Authors: Krangel MS, Band H, Hata S, McLean J, Brenner MB.
Science 1987-07-03
View full abstract on Pubmed

Amplification of IMR-32 clones 8, G21, and N-myc in human neuroblastoma xenografts.

Authors: Authors: Kanda N, Tsuchida Y, Hata J, Kohl NE, Alt FW, Latt SA, Utakoji T.
Cancer Res 1987-06-15
View full abstract on Pubmed

T3 glycoprotein is functional although structurally distinct on human T-cell receptor gamma T lymphocytes.

Authors: Authors: Krangel MS, Bierer BE, Devlin P, Clabby M, Strominger JL, McLean J, Brenner MB.
Proc Natl Acad Sci U S A 1987-06-01
View full abstract on Pubmed

Circular T-cell receptor gene recombination products.

Authors: Authors: Alt FW, Yancopoulos GD.
Nature 1987-05-21
View full abstract on Pubmed

Isolation of anti-idiotypic antibodies to T cells using an anti-framework determinant antibody.

Authors: Authors: Maecker HT, Kitamura K, Brenner MB, Levy R.
J Immunol Methods 1987-04-16
View full abstract on Pubmed

High frequency of autoantibodies bearing cross-reactive idiotopes among hybridomas using VH7183 genes prepared from normal and autoimmune murine strains.

Authors: Authors: Bellon B, Manheimer-Lory A, Monestier M, Moran T, Dimitriu-Bona A, Alt F, Bona C.
J Clin Invest 1987-04-01
View full abstract on Pubmed

Two forms of the T-cell receptor gamma protein found on peripheral blood cytotoxic T lymphocytes.

Authors: Authors: Brenner MB, McLean J, Scheft H, Riberdy J, Ang SL, Seidman JG, Devlin P, Krangel MS.
Nature 1987-03-19
View full abstract on Pubmed

Characterization and expression of the human alpha beta T cell receptor by using a framework monoclonal antibody.

Authors: Authors: Brenner MB, McLean J, Scheft H, Warnke RA, Jones N, Strominger JL.
J Immunol 1987-03-01
View full abstract on Pubmed

Immunoglobulin heavy chain switch region recombination within a retroviral vector in murine pre-B cells.

Authors: Authors: Ott DE, Alt FW, Marcu KB.
EMBO J 1987-03-01
View full abstract on Pubmed