Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Activation of V kappa gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains.

Authors: Authors: Reth M, Petrac E, Wiese P, Lobel L, Alt FW.
EMBO J 1987-11-01
View full abstract on Pubmed

Structure and expression of the murine L-myc gene.

Authors: Authors: Legouy E, DePinho R, Zimmerman K, Collum R, Yancopoulos G, Mitsock L, Kriz R, Alt FW.
EMBO J 1987-11-01
View full abstract on Pubmed

Immunochemical proof that a novel rearranging gene encodes the T cell receptor delta subunit.

Authors: Authors: Band H, Hochstenbach F, McLean J, Hata S, Krangel MS, Brenner MB.
Science 1987-10-30
View full abstract on Pubmed

Identification of putative human T cell receptor delta complementary DNA clones.

Authors: Authors: Hata S, Brenner MB, Krangel MS.
Science 1987-10-30
View full abstract on Pubmed

T-cell receptors of human suppressor cells.

Authors: Authors: Modlin RL, Brenner MB, Krangel MS, Duby AD, Bloom BR.
Nature 1987-10-08
View full abstract on Pubmed

Structurally divergent human T cell receptor gamma proteins encoded by distinct C gamma genes.

Authors: Authors: Krangel MS, Band H, Hata S, McLean J, Brenner MB.
Science 1987-07-03
View full abstract on Pubmed

Amplification of IMR-32 clones 8, G21, and N-myc in human neuroblastoma xenografts.

Authors: Authors: Kanda N, Tsuchida Y, Hata J, Kohl NE, Alt FW, Latt SA, Utakoji T.
Cancer Res 1987-06-15
View full abstract on Pubmed

T3 glycoprotein is functional although structurally distinct on human T-cell receptor gamma T lymphocytes.

Authors: Authors: Krangel MS, Bierer BE, Devlin P, Clabby M, Strominger JL, McLean J, Brenner MB.
Proc Natl Acad Sci U S A 1987-06-01
View full abstract on Pubmed

Circular T-cell receptor gene recombination products.

Authors: Authors: Alt FW, Yancopoulos GD.
Nature 1987-05-21
View full abstract on Pubmed

Isolation of anti-idiotypic antibodies to T cells using an anti-framework determinant antibody.

Authors: Authors: Maecker HT, Kitamura K, Brenner MB, Levy R.
J Immunol Methods 1987-04-16
View full abstract on Pubmed