Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

High frequency of autoantibodies bearing cross-reactive idiotopes among hybridomas using VH7183 genes prepared from normal and autoimmune murine strains.

Authors: Authors: Bellon B, Manheimer-Lory A, Monestier M, Moran T, Dimitriu-Bona A, Alt F, Bona C.
J Clin Invest 1987-04-01
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Two forms of the T-cell receptor gamma protein found on peripheral blood cytotoxic T lymphocytes.

Authors: Authors: Brenner MB, McLean J, Scheft H, Riberdy J, Ang SL, Seidman JG, Devlin P, Krangel MS.
Nature 1987-03-19
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Characterization and expression of the human alpha beta T cell receptor by using a framework monoclonal antibody.

Authors: Authors: Brenner MB, McLean J, Scheft H, Warnke RA, Jones N, Strominger JL.
J Immunol 1987-03-01
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Immunoglobulin heavy chain switch region recombination within a retroviral vector in murine pre-B cells.

Authors: Authors: Ott DE, Alt FW, Marcu KB.
EMBO J 1987-03-01
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T cell receptor B chain rearrangements in human suppressor T lymphocytes.

Authors: Authors: Rohowsky-Kochan C, Kowal C, King DW, Alt FW, Suciu-Foca N.
Transplant Proc 1987-02-01
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Differentiation antigens associated with the function of alloreactive T lymphocytes.

Authors: Authors: Kowal C, Rohowsky-Kochan C, Cristea E, Cai J, Rosochacki S, Lungu O, King DW, Alt FW, Suciu-Foca N.
Transplant Proc 1987-02-01
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Expression of the immunoglobulin heavy-chain variable gene repertoire.

Authors: Authors: Malynn BA, Berman JE, Yancopoulos GD, Bona CA, Alt FW.
Curr Top Microbiol Immunol 1987-01-01
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Recombination between immunoglobulin variable region gene segments is enhanced by transcription.

Authors: Authors: Blackwell TK, Moore MW, Yancopoulos GD, Suh H, Lutzker S, Selsing E, Alt FW.
Nature 1986-12-11
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Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching.

Authors: Authors: Yancopoulos GD, DePinho RA, Zimmerman KA, Lutzker SG, Rosenberg N, Alt FW.
EMBO J 1986-12-01
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Enhanced expression of the N-myc gene in Wilms' tumors.

Authors: Authors: Nisen PD, Zimmerman KA, Cotter SV, Gilbert F, Alt FW.
Cancer Res 1986-12-01
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