Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Differentiation antigens associated with the function of alloreactive T lymphocytes.

Authors: Authors: Kowal C, Rohowsky-Kochan C, Cristea E, Cai J, Rosochacki S, Lungu O, King DW, Alt FW, Suciu-Foca N.
Transplant Proc 1987-02-01
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T cell receptor B chain rearrangements in human suppressor T lymphocytes.

Authors: Authors: Rohowsky-Kochan C, Kowal C, King DW, Alt FW, Suciu-Foca N.
Transplant Proc 1987-02-01
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Expression of the immunoglobulin heavy-chain variable gene repertoire.

Authors: Authors: Malynn BA, Berman JE, Yancopoulos GD, Bona CA, Alt FW.
Curr Top Microbiol Immunol 1987-01-01
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Recombination between immunoglobulin variable region gene segments is enhanced by transcription.

Authors: Authors: Blackwell TK, Moore MW, Yancopoulos GD, Suh H, Lutzker S, Selsing E, Alt FW.
Nature 1986-12-11
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Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching.

Authors: Authors: Yancopoulos GD, DePinho RA, Zimmerman KA, Lutzker SG, Rosenberg N, Alt FW.
EMBO J 1986-12-01
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Enhanced expression of the N-myc gene in Wilms' tumors.

Authors: Authors: Nisen PD, Zimmerman KA, Cotter SV, Gilbert F, Alt FW.
Cancer Res 1986-12-01
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Fine specificity, idiotypy, and nature of cloned heavy-chain variable region genes of murine monoclonal rheumatoid factor antibodies.

Authors: Authors: Manheimer-Lory AJ, Monestier M, Bellon B, Alt FW, Bona CA.
Proc Natl Acad Sci U S A 1986-11-01
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Regulation fo immunoglobulin variable region gene assembly: development of the primary antibody repertoire.

Authors: Authors: Berman JE, Malynn BA, Blackwell TK, Alt FW.
Bioessays 1986-11-01
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Amplification and rearrangement of DNA sequences from the chromosomal region 2p24 in human neuroblastomas.

Authors: Authors: Shiloh Y, Korf B, Kohl NE, Sakai K, Brodeur GM, Harris P, Kanda N, Seeger RC, Alt F, Latt SA.
Cancer Res 1986-10-01
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VHDJH formation and DJH replacement during pre-B differentiation: non-random usage of gene segments.

Authors: Authors: Reth MG, Jackson S, Alt FW.
EMBO J 1986-09-01
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