Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Immunoglobulin heavy chain gene rearrangements in X-linked agammaglobulinemia.
Authors: Authors: Mensink EJ, Schuurman RK, Schot JD, Thompson A, Alt FW.
Eur J Immunol
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A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes.
Authors: Authors: Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L.
Nature
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Identification of a putative second T-cell receptor.
Authors: Authors: Brenner MB, McLean J, Dialynas DP, Strominger JL, Smith JA, Owen FL, Seidman JG, Ip S, Rosen F, Krangel MS.
Nature
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A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes.
Authors: Authors: Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L.
Nature
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Regulation of immunoglobulin variable-region gene assembly.
Authors: Authors: Alt FW, Reth MG, Blackwell TK, Yancopoulos GD.
Mt Sinai J Med
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Structure and expression of the murine N-myc gene.
Authors: Authors: DePinho RA, Legouy E, Feldman LB, Kohl NE, Yancopoulos GD, Alt FW.
Proc Natl Acad Sci U S A
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Regulation of genome rearrangement events during lymphocyte differentiation.
Authors: Authors: Alt FW, Blackwell TK, DePinho RA, Reth MG, Yancopoulos GD.
Immunol Rev
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Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinase.
Authors: Authors: Yancopoulos GD, Blackwell TK, Suh H, Hood L, Alt FW.
Cell
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Human N-myc is closely related in organization and nucleotide sequence to c-myc.
Authors: Authors: Kohl NE, Legouy E, DePinho RA, Nisen PD, Smith RK, Gee CE, Alt FW.
Nature
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Regulation of the assembly and expression of variable-region genes.
Authors: Authors: Yancopoulos GD, Alt FW.
Annu Rev Immunol
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