Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Fine specificity, idiotypy, and nature of cloned heavy-chain variable region genes of murine monoclonal rheumatoid factor antibodies.

Authors: Authors: Manheimer-Lory AJ, Monestier M, Bellon B, Alt FW, Bona CA.
Proc Natl Acad Sci U S A 1986-11-01
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Regulation fo immunoglobulin variable region gene assembly: development of the primary antibody repertoire.

Authors: Authors: Berman JE, Malynn BA, Blackwell TK, Alt FW.
Bioessays 1986-11-01
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Amplification and rearrangement of DNA sequences from the chromosomal region 2p24 in human neuroblastomas.

Authors: Authors: Shiloh Y, Korf B, Kohl NE, Sakai K, Brodeur GM, Harris P, Kanda N, Seeger RC, Alt F, Latt SA.
Cancer Res 1986-10-01
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VHDJH formation and DJH replacement during pre-B differentiation: non-random usage of gene segments.

Authors: Authors: Reth MG, Jackson S, Alt FW.
EMBO J 1986-09-01
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Immunoglobulin heavy chain gene rearrangements in X-linked agammaglobulinemia.

Authors: Authors: Mensink EJ, Schuurman RK, Schot JD, Thompson A, Alt FW.
Eur J Immunol 1986-08-01
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A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes.

Authors: Authors: Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L.
Nature 1986-07-10
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A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes.

Authors: Authors: Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L.
Nature 1986-07-10
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Identification of a putative second T-cell receptor.

Authors: Authors: Brenner MB, McLean J, Dialynas DP, Strominger JL, Smith JA, Owen FL, Seidman JG, Ip S, Rosen F, Krangel MS.
Nature 1986-07-10
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Structure and expression of the murine N-myc gene.

Authors: Authors: DePinho RA, Legouy E, Feldman LB, Kohl NE, Yancopoulos GD, Alt FW.
Proc Natl Acad Sci U S A 1986-03-01
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Regulation of immunoglobulin variable-region gene assembly.

Authors: Authors: Alt FW, Reth MG, Blackwell TK, Yancopoulos GD.
Mt Sinai J Med 1986-03-01
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