Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Neural blastocyst complementation enables mouse forebrain organogenesis.

Authors: Authors: Chang AN, Liang Z, Dai HQ, Chapdelaine-Williams AM, Andrews N, Bronson RT, Schwer B, Alt FW.
Nature 2018-11-01
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DNA double-strand breaks as drivers of neural genomic change, function, and disease.

Authors: Authors: Alt FW, Schwer B.
DNA Repair (Amst) 2018-11-01
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Mixed-effects association of single cells identifies an expanded effector CD4+ T cell subset in rheumatoid arthritis.

Authors: Authors: Fonseka CY, Rao DA, Teslovich NC, Korsunsky I, Hannes SK, Slowikowski K, Gurish MF, Donlin LT, Lederer JA, Weinblatt ME, Massarotti EM, Coblyn JS, Helfgott SM, Todd DJ, Bykerk VP, Karlson EW, Ermann J, Lee YC, Brenner MB, Raychaudhuri S.
Sci Transl Med 2018-10-17
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Parp3 promotes long-range end joining in murine cells.

Authors: Authors: Layer JV, Cleary JP, Brown AJ, Stevenson KE, Morrow SN, Van Scoyk A, Blasco RB, Karaca E, Meng FL, Frock RL, Tivey T, Kim S, Fuchs H, Chiarle R, Alt FW, Roberts SA, Weinstock DM, Day TA.
Proc Natl Acad Sci U S A 2018-10-02
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Guiding a mutator in antibody diversification.

Authors: Authors: Tian M, Alt FW.
Cell Res 2018-10-01
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Innate T Cells Govern Adipose Tissue Biology.

Authors: Authors: LaMarche NM, Kohlgruber AC, Brenner MB.
J Immunol 2018-10-01
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Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies.

Authors: Authors: Duan H, Chen X, Boyington JC, Cheng C, Zhang Y, Jafari AJ, Stephens T, Tsybovsky Y, Kalyuzhniy O, Zhao P, Menis S, Nason MC, Normandin E, Mukhamedova M, DeKosky BJ, Wells L, Schief WR, Tian M, Alt FW, Kwong PD, Mascola JR.
Immunity 2018-08-21
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Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination.

Authors: Authors: Crowe JL, Shao Z, Wang XS, Wei PC, Jiang W, Lee BJ, Estes VM, Alt FW, Zha S.
Proc Natl Acad Sci U S A 2018-08-21
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High-throughput identification of noncoding functional SNPs via type IIS enzyme restriction.

Authors: Authors: Li G, Martínez-Bonet M, Wu D, Yang Y, Cui J, Nguyen HN, Cunin P, Levescot A, Bai M, Westra HJ, Okada Y, Brenner MB, Raychaudhuri S, Hendrickson EA, Maas RL, Nigrovic PA.
Nat Genet 2018-08-01
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DNA melting initiates the RAG catalytic pathway.

Authors: Authors: Ru H, Mi W, Zhang P, Alt FW, Schatz DG, Liao M, Wu H.
Nat Struct Mol Biol 2018-08-01
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