Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

The human myc gene family.

Authors: Authors: Alt FW, DePinho R, Zimmerman K, Legouy E, Hatton K, Ferrier P, Tesfaye A, Yancopoulos G, Nisen P.
Cold Spring Harb Symp Quant Biol 1986-01-01
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Regulation of the assembly and expression of variable-region genes.

Authors: Authors: Yancopoulos GD, Alt FW.
Annu Rev Immunol 1986-01-01
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N-myc can cooperate with ras to transform normal cells in culture.

Authors: Authors: Yancopoulos GD, Nisen PD, Tesfaye A, Kohl NE, Goldfarb MP, Alt FW.
Proc Natl Acad Sci U S A 1985-08-01
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Clonal T lymphocyte recognition of the fine structure of the HLA-A2 molecule.

Authors: Authors: Brenner MB, McLean J, Yang SY, van der Poel JJ, Pious D, Strominger JL.
J Immunol 1985-07-01
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VLA-1: a T cell surface antigen which defines a novel late stage of human T cell activation.

Authors: Authors: Hemler ME, Jacobson JG, Brenner MB, Mann D, Strominger JL.
Eur J Immunol 1985-05-01
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Developmentally controlled and tissue-specific expression of unrearranged VH gene segments.

Authors: Authors: Yancopoulos GD, Alt FW.
Cell 1985-02-01
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Cross-linking of human T cell receptor proteins: association between the T cell idiotype beta subunit and the T3 glycoprotein heavy subunit.

Authors: Authors: Brenner MB, Trowbridge IS, Strominger JL.
Cell 1985-01-01
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Activated expression of the N-myc gene in human neuroblastomas and related tumors.

Authors: Authors: Kohl NE, Gee CE, Alt FW.
Science 1984-12-14
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Exclusive immunoglobulin genes.

Authors: Authors: Alt FW.
Nature 1984-12-06
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Molecular basis of heavy-chain class switching and switch region deletion in an Abelson virus-transformed cell line.

Authors: Authors: DePinho R, Kruger K, Andrews N, Lutzker S, Baltimore D, Alt FW.
Mol Cell Biol 1984-12-01
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