Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Regulation of genome rearrangement events during lymphocyte differentiation.

Authors: Authors: Alt FW, Blackwell TK, DePinho RA, Reth MG, Yancopoulos GD.
Immunol Rev 1986-02-01
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Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinase.

Authors: Authors: Yancopoulos GD, Blackwell TK, Suh H, Hood L, Alt FW.
Cell 1986-01-31
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Human N-myc is closely related in organization and nucleotide sequence to c-myc.

Authors: Authors: Kohl NE, Legouy E, DePinho RA, Nisen PD, Smith RK, Gee CE, Alt FW.
Nature 1986-01-02
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Regulation of the assembly and expression of variable-region genes.

Authors: Authors: Yancopoulos GD, Alt FW.
Annu Rev Immunol 1986-01-01
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Myc family genes: a dispersed multi-gene family.

Authors: Authors: Depinho RA, Hatton K, Ferrier P, Zimmerman K, Legouy E, Tesfaye A, Collum R, Yancopoulos G, Nisen P, Alt F.
Ann Clin Res 1986-01-01
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The human myc gene family.

Authors: Authors: Alt FW, DePinho R, Zimmerman K, Legouy E, Hatton K, Ferrier P, Tesfaye A, Yancopoulos G, Nisen P.
Cold Spring Harb Symp Quant Biol 1986-01-01
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N-myc can cooperate with ras to transform normal cells in culture.

Authors: Authors: Yancopoulos GD, Nisen PD, Tesfaye A, Kohl NE, Goldfarb MP, Alt FW.
Proc Natl Acad Sci U S A 1985-08-01
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Clonal T lymphocyte recognition of the fine structure of the HLA-A2 molecule.

Authors: Authors: Brenner MB, McLean J, Yang SY, van der Poel JJ, Pious D, Strominger JL.
J Immunol 1985-07-01
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VLA-1: a T cell surface antigen which defines a novel late stage of human T cell activation.

Authors: Authors: Hemler ME, Jacobson JG, Brenner MB, Mann D, Strominger JL.
Eur J Immunol 1985-05-01
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Developmentally controlled and tissue-specific expression of unrearranged VH gene segments.

Authors: Authors: Yancopoulos GD, Alt FW.
Cell 1985-02-01
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