Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells.

Authors: Authors: Desiderio SV, Yancopoulos GD, Paskind M, Thomas E, Boss MA, Landau N, Alt FW, Baltimore D.
Nature 1984-10-25
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Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines.

Authors: Authors: Yancopoulos GD, Desiderio SV, Paskind M, Kearney JF, Baltimore D, Alt FW.
Nature 1984-10-25
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A study of the specificity of the direct binding between bacteria and HLA antigens.

Authors: Authors: Maeda K, Kono D, Kobayashi S, Brenner MB, Yu DT.
Clin Exp Immunol 1984-09-01
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Identification of shared antigenic determinants of the putative human T lymphocyte antigen receptor.

Authors: Authors: Brenner MB, Trowbridge IS, McLean J, Strominger JL.
J Exp Med 1984-08-01
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Ordered rearrangement of immunoglobulin heavy chain variable region segments.

Authors: Authors: Alt FW, Yancopoulos GD, Blackwell TK, Wood C, Thomas E, Boss M, Coffman R, Rosenberg N, Tonegawa S, Baltimore D.
EMBO J 1984-06-01
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Site-specific recombination between immunoglobulin D and JH segments that were introduced into the genome of a murine pre-B cell line.

Authors: Authors: Blackwell TK, Alt FW.
Cell 1984-05-01
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Antigenic stimulation regulates the level of expression of interleukin 2 receptor on human T cells.

Authors: Authors: Hemler ME, Brenner MB, McLean JM, Strominger JL.
Proc Natl Acad Sci U S A 1984-04-01
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In vitro T lymphocyte proliferative response to Yersinia enterocolitica in Reiter's syndrome. Lack of response in other HLA-B27 positive individuals.

Authors: Authors: Brenner MB, Kobayashi S, Wiesenhutter CW, Huberman AK, Bales P, Yu DT.
Arthritis Rheum 1984-03-01
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Transposition and amplification of oncogene-related sequences in human neuroblastomas.

Authors: Authors: Kohl NE, Kanda N, Schreck RR, Bruns G, Latt SA, Gilbert F, Alt FW.
Cell 1983-12-01
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Isolation of amplified DNA sequences from IMR-32 human neuroblastoma cells: facilitation by fluorescence-activated flow sorting of metaphase chromosomes.

Authors: Authors: Kanda N, Schreck R, Alt F, Bruns G, Baltimore D, Latt S.
Proc Natl Acad Sci U S A 1983-07-01
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