Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Clonal T lymphocyte recognition of the fine structure of the HLA-A2 molecule.

Authors: Authors: Brenner MB, McLean J, Yang SY, van der Poel JJ, Pious D, Strominger JL.
J Immunol 1985-07-01
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VLA-1: a T cell surface antigen which defines a novel late stage of human T cell activation.

Authors: Authors: Hemler ME, Jacobson JG, Brenner MB, Mann D, Strominger JL.
Eur J Immunol 1985-05-01
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Developmentally controlled and tissue-specific expression of unrearranged VH gene segments.

Authors: Authors: Yancopoulos GD, Alt FW.
Cell 1985-02-01
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Cross-linking of human T cell receptor proteins: association between the T cell idiotype beta subunit and the T3 glycoprotein heavy subunit.

Authors: Authors: Brenner MB, Trowbridge IS, Strominger JL.
Cell 1985-01-01
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Activated expression of the N-myc gene in human neuroblastomas and related tumors.

Authors: Authors: Kohl NE, Gee CE, Alt FW.
Science 1984-12-14
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Exclusive immunoglobulin genes.

Authors: Authors: Alt FW.
Nature 1984-12-06
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Molecular basis of heavy-chain class switching and switch region deletion in an Abelson virus-transformed cell line.

Authors: Authors: DePinho R, Kruger K, Andrews N, Lutzker S, Baltimore D, Alt FW.
Mol Cell Biol 1984-12-01
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Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells.

Authors: Authors: Desiderio SV, Yancopoulos GD, Paskind M, Thomas E, Boss MA, Landau N, Alt FW, Baltimore D.
Nature 1984-10-25
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Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines.

Authors: Authors: Yancopoulos GD, Desiderio SV, Paskind M, Kearney JF, Baltimore D, Alt FW.
Nature 1984-10-25
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A study of the specificity of the direct binding between bacteria and HLA antigens.

Authors: Authors: Maeda K, Kono D, Kobayashi S, Brenner MB, Yu DT.
Clin Exp Immunol 1984-09-01
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