Frederick Ausubel headshot
Frederick M. Ausubel, Ph.D
Professor of Genetics, Emeritus

The Ausubel laboratory uses genetic, genomic, and chemical genetic approaches to: (1) elucidate the molecular basis of microbial pathogenesis in the bacterial pathogens Pseudomonas aeruginosa and Pseudomonas syringae and (2) identify the components of the signaling pathways involved in the host innate immune response in the plant Arabidopsis thaliana and the nematode Caenorhabditis elegans.

Generation of Fluorinated Amychelin Siderophores against Pseudomonas aeruginosa Infections by a Combination of Genome Mining and Mutasynthesis.
Authors: Authors: Xie F, Dai S, Zhao Y, Huang P, Yu S, Ren B, Wang Q, Ji Z, Alterovitz G, Zhang Q, Zhang J, Chen X, Jiang L, Song F, Liu H, Ausubel FM, Liu X, Dai H, Zhang L.
Cell Chem Biol
View full abstract on Pubmed
In the Model Host Caenorhabditis elegans, Sphingosine-1-Phosphate-Mediated Signaling Increases Immunity toward Human Opportunistic Bacteria.
Authors: Authors: Lee K, Escobar I, Jang Y, Kim W, Ausubel FM, Mylonakis E.
Int J Mol Sci
View full abstract on Pubmed
Characterization of Five Novel Anti-MRSA Compounds Identified Using a Whole-Animal Caenorhabditis elegans/Galleria mellonella Sequential-Screening Approach.
Authors: Authors: Khader R, Tharmalingam N, Mishra B, Felix L, Ausubel FM, Kelso MJ, Mylonakis E.
Antibiotics (Basel)
View full abstract on Pubmed
The Neutrally Charged Diarylurea Compound PQ401 Kills Antibiotic-Resistant and Antibiotic-Tolerant Staphylococcus aureus.
Authors: Authors: Kim W, Zou G, Pan W, Fricke N, Faizi HA, Kim SM, Khader R, Li S, Lee K, Escorba I, Vlahovska PM, Gao H, Ausubel FM, Mylonakis E.
View full abstract on Pubmed
The Pseudomonas aeruginosa accessory genome elements influence virulence towards Caenorhabditis elegans.
Authors: Authors: Vasquez-Rifo A, Veksler-Lublinsky I, Cheng Z, Ausubel FM, Ambros V.
Genome Biol
View full abstract on Pubmed
A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus.
Authors: Authors: Kim W, Zou G, Hari TPA, Wilt IK, Zhu W, Galle N, Faizi HA, Hendricks GL, Tori K, Pan W, Huang X, Steele AD, Csatary EE, Dekarske MM, Rosen JL, Ribeiro NQ, Lee K, Port J, Fuchs BB, Vlahovska PM, Wuest WM, Gao H, Ausubel FM, Mylonakis E.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Both live and dead Enterococci activate Caenorhabditis elegans host defense via immune and stress pathways.
Authors: Authors: Yuen GJ, Ausubel FM.
View full abstract on Pubmed
Tracing My Roots: How I Became a Plant Biologist.
Authors: Authors: Ausubel FM.
Annu Rev Genet
View full abstract on Pubmed
Discovery and Optimization of nTZDpa as an Antibiotic Effective Against Bacterial Persisters.
Authors: Authors: Kim W, Steele AD, Zhu W, Csatary EE, Fricke N, Dekarske MM, Jayamani E, Pan W, Kwon B, Sinitsa IF, Rosen JL, Conery AL, Fuchs BB, Vlahovska PM, Ausubel FM, Gao H, Wuest WM, Mylonakis E.
ACS Infect Dis
View full abstract on Pubmed
Replication of the Ordered, Nonredundant Library of Pseudomonas aeruginosa strain PA14 Transposon Insertion Mutants.
Authors: Authors: Drenkard E, Hibbler RM, Gutu DA, Eaton AD, Silverio AL, Ausubel FM, Hurley BP, Yonker LM.
J Vis Exp
View full abstract on Pubmed