Frederick Ausubel headshot
Frederick M. Ausubel, Ph.D
Professor of Genetics, Emeritus

The Ausubel laboratory uses genetic, genomic, and chemical genetic approaches to: (1) elucidate the molecular basis of microbial pathogenesis in the bacterial pathogens Pseudomonas aeruginosa and Pseudomonas syringae and (2) identify the components of the signaling pathways involved in the host innate immune response in the plant Arabidopsis thaliana and the nematode Caenorhabditis elegans.

Antimicrobial activity of the membrane-active compound nTZDpa is enhanced at low pH.
Authors: Authors: Kim SM, Zou G, Kim H, Kang M, Ahn S, Heo HY, Kim JS, Lim KM, Ausubel FM, Mylonakis E, Gao H, Kim W.
Biomed Pharmacother
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ABCDs of the Relative Contributions of Pseudomonas aeruginosa Quorum Sensing Systems to Virulence in Diverse Nonvertebrate Hosts.
Authors: Authors: Vasquez-Rifo A, Cook J, McEwan DL, Shikara D, Ausubel FM, Di Cara F, Cheng Z.
mBio
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Generation of Fluorinated Amychelin Siderophores against Pseudomonas aeruginosa Infections by a Combination of Genome Mining and Mutasynthesis.
Authors: Authors: Xie F, Dai S, Zhao Y, Huang P, Yu S, Ren B, Wang Q, Ji Z, Alterovitz G, Zhang Q, Zhang J, Chen X, Jiang L, Song F, Liu H, Ausubel FM, Liu X, Dai H, Zhang L.
Cell Chem Biol
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In the Model Host Caenorhabditis elegans, Sphingosine-1-Phosphate-Mediated Signaling Increases Immunity toward Human Opportunistic Bacteria.
Authors: Authors: Lee K, Escobar I, Jang Y, Kim W, Ausubel FM, Mylonakis E.
Int J Mol Sci
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Characterization of Five Novel Anti-MRSA Compounds Identified Using a Whole-Animal Caenorhabditis elegans/Galleria mellonella Sequential-Screening Approach.
Authors: Authors: Khader R, Tharmalingam N, Mishra B, Felix L, Ausubel FM, Kelso MJ, Mylonakis E.
Antibiotics (Basel)
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The Neutrally Charged Diarylurea Compound PQ401 Kills Antibiotic-Resistant and Antibiotic-Tolerant Staphylococcus aureus.
Authors: Authors: Kim W, Zou G, Pan W, Fricke N, Faizi HA, Kim SM, Khader R, Li S, Lee K, Escorba I, Vlahovska PM, Gao H, Ausubel FM, Mylonakis E.
mBio
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The Pseudomonas aeruginosa accessory genome elements influence virulence towards Caenorhabditis elegans.
Authors: Authors: Vasquez-Rifo A, Veksler-Lublinsky I, Cheng Z, Ausubel FM, Ambros V.
Genome Biol
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A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus.
Authors: Authors: Kim W, Zou G, Hari TPA, Wilt IK, Zhu W, Galle N, Faizi HA, Hendricks GL, Tori K, Pan W, Huang X, Steele AD, Csatary EE, Dekarske MM, Rosen JL, Ribeiro NQ, Lee K, Port J, Fuchs BB, Vlahovska PM, Wuest WM, Gao H, Ausubel FM, Mylonakis E.
Proc Natl Acad Sci U S A
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Both live and dead Enterococci activate Caenorhabditis elegans host defense via immune and stress pathways.
Authors: Authors: Yuen GJ, Ausubel FM.
Virulence
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Tracing My Roots: How I Became a Plant Biologist.
Authors: Authors: Ausubel FM.
Annu Rev Genet
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