The Ausubel laboratory uses genetic, genomic, and chemical genetic approaches to: (1) elucidate the molecular basis of microbial pathogenesis in the bacterial pathogens Pseudomonas aeruginosa and Pseudomonas syringae and (2) identify the components of the signaling pathways involved in the host innate immune response in the plant Arabidopsis thaliana and the nematode Caenorhabditis elegans.
The Pseudomonas aeruginosa accessory genome elements influence virulence towards Caenorhabditis elegans.
Authors: Authors: Vasquez-Rifo A, Veksler-Lublinsky I, Cheng Z, Ausubel FM, Ambros V.
Genome Biol
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Genome Biol
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A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus.
Authors: Authors: Kim W, Zou G, Hari TPA, Wilt IK, Zhu W, Galle N, Faizi HA, Hendricks GL, Tori K, Pan W, Huang X, Steele AD, Csatary EE, Dekarske MM, Rosen JL, Ribeiro NQ, Lee K, Port J, Fuchs BB, Vlahovska PM, Wuest WM, Gao H, Ausubel FM, Mylonakis E.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Both live and dead Enterococci activate Caenorhabditis elegans host defense via immune and stress pathways.
Tracing My Roots: How I Became a Plant Biologist.
Discovery and Optimization of nTZDpa as an Antibiotic Effective Against Bacterial Persisters.
Authors: Authors: Kim W, Steele AD, Zhu W, Csatary EE, Fricke N, Dekarske MM, Jayamani E, Pan W, Kwon B, Sinitsa IF, Rosen JL, Conery AL, Fuchs BB, Vlahovska PM, Ausubel FM, Gao H, Wuest WM, Mylonakis E.
ACS Infect Dis
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ACS Infect Dis
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Replication of the Ordered, Nonredundant Library of Pseudomonas aeruginosa strain PA14 Transposon Insertion Mutants.
Authors: Authors: Drenkard E, Hibbler RM, Gutu DA, Eaton AD, Silverio AL, Ausubel FM, Hurley BP, Yonker LM.
J Vis Exp
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J Vis Exp
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Quorum-sensing regulator RhlR but not its autoinducer RhlI enables Pseudomonas to evade opsonization.
Authors: Authors: Haller S, Franchet A, Hakkim A, Chen J, Drenkard E, Yu S, Schirmeier S, Li Z, Martins N, Ausubel FM, Liégeois S, Ferrandon D.
EMBO Rep
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EMBO Rep
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A new class of synthetic retinoid antibiotics effective against bacterial persisters.
Authors: Authors: Kim W, Zhu W, Hendricks GL, Van Tyne D, Steele AD, Keohane CE, Fricke N, Conery AL, Shen S, Pan W, Lee K, Rajamuthiah R, Fuchs BB, Vlahovska PM, Wuest WM, Gilmore MS, Gao H, Ausubel FM, Mylonakis E.
Nature
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Nature
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Overview of Next-Generation Sequencing Technologies.
Authors: Authors: Slatko BE, Gardner AF, Ausubel FM.
Curr Protoc Mol Biol
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Curr Protoc Mol Biol
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Rhizosphere-associated Pseudomonas induce systemic resistance to herbivores at the cost of susceptibility to bacterial pathogens.
Authors: Authors: Haney CH, Wiesmann CL, Shapiro LR, Melnyk RA, O'Sullivan LR, Khorasani S, Xiao L, Han J, Bush J, Carrillo J, Pierce NE, Ausubel FM.
Mol Ecol
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Mol Ecol
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