The Ausubel laboratory uses genetic, genomic, and chemical genetic approaches to: (1) elucidate the molecular basis of microbial pathogenesis in the bacterial pathogens Pseudomonas aeruginosa and Pseudomonas syringae and (2) identify the components of the signaling pathways involved in the host innate immune response in the plant Arabidopsis thaliana and the nematode Caenorhabditis elegans.
Models of Caenorhabditis elegans infection by bacterial and fungal pathogens.
A metasystem of framework model organisms to study emergence of new host-microbe adaptations.
BifA, a cyclic-Di-GMP phosphodiesterase, inversely regulates biofilm formation and swarming motility by Pseudomonas aeruginosa PA14.
Authors: Authors: Kuchma SL, Brothers KM, Merritt JH, Liberati NT, Ausubel FM, O'Toole GA.
J Bacteriol
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J Bacteriol
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Exploiting amoeboid and non-vertebrate animal model systems to study the virulence of human pathogenic fungi.
Characterization of the integrated filamentous phage Pf5 and its involvement in small-colony formation.
Authors: Authors: Mooij MJ, Drenkard E, Llamas MA, Vandenbroucke-Grauls CM, Savelkoul PH, Ausubel FM, Bitter W.
Microbiology
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Microbiology
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Resistance to Botrytis cinerea induced in Arabidopsis by elicitors is independent of salicylic acid, ethylene, or jasmonate signaling but requires PHYTOALEXIN DEFICIENT3.
Authors: Authors: Ferrari S, Galletti R, Denoux C, De Lorenzo G, Ausubel FM, Dewdney J.
Plant Physiol
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Plant Physiol
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Staphylococcal biofilm exopolysaccharide protects against Caenorhabditis elegans immune defenses.
Authors: Authors: Begun J, Gaiani JM, Rohde H, Mack D, Calderwood SB, Ausubel FM, Sifri CD.
PLoS Pathog
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PLoS Pathog
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Antifungal chemical compounds identified using a C. elegans pathogenicity assay.
Authors: Authors: Breger J, Fuchs BB, Aperis G, Moy TI, Ausubel FM, Mylonakis E.
PLoS Pathog
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PLoS Pathog
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Prospects for plant-derived antibacterials.
p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans.
Authors: Authors: Troemel ER, Chu SW, Reinke V, Lee SS, Ausubel FM, Kim DH.
PLoS Genet
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PLoS Genet
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