The Ausubel laboratory uses genetic, genomic, and chemical genetic approaches to: (1) elucidate the molecular basis of microbial pathogenesis in the bacterial pathogens Pseudomonas aeruginosa and Pseudomonas syringae and (2) identify the components of the signaling pathways involved in the host innate immune response in the plant Arabidopsis thaliana and the nematode Caenorhabditis elegans.
Comparing insertion libraries in two Pseudomonas aeruginosa strains to assess gene essentiality.
Authors: Authors: Liberati NT, Urbach JM, Thurber TK, Wu G, Ausubel FM.
Methods Mol Biol
View full abstract on Pubmed
Methods Mol Biol
View full abstract on Pubmed
BifA, a cyclic-Di-GMP phosphodiesterase, inversely regulates biofilm formation and swarming motility by Pseudomonas aeruginosa PA14.
Authors: Authors: Kuchma SL, Brothers KM, Merritt JH, Liberati NT, Ausubel FM, O'Toole GA.
J Bacteriol
View full abstract on Pubmed
J Bacteriol
View full abstract on Pubmed
Exploiting amoeboid and non-vertebrate animal model systems to study the virulence of human pathogenic fungi.
Characterization of the integrated filamentous phage Pf5 and its involvement in small-colony formation.
Authors: Authors: Mooij MJ, Drenkard E, Llamas MA, Vandenbroucke-Grauls CM, Savelkoul PH, Ausubel FM, Bitter W.
Microbiology
View full abstract on Pubmed
Microbiology
View full abstract on Pubmed
Resistance to Botrytis cinerea induced in Arabidopsis by elicitors is independent of salicylic acid, ethylene, or jasmonate signaling but requires PHYTOALEXIN DEFICIENT3.
Authors: Authors: Ferrari S, Galletti R, Denoux C, De Lorenzo G, Ausubel FM, Dewdney J.
Plant Physiol
View full abstract on Pubmed
Plant Physiol
View full abstract on Pubmed
Staphylococcal biofilm exopolysaccharide protects against Caenorhabditis elegans immune defenses.
Authors: Authors: Begun J, Gaiani JM, Rohde H, Mack D, Calderwood SB, Ausubel FM, Sifri CD.
PLoS Pathog
View full abstract on Pubmed
PLoS Pathog
View full abstract on Pubmed
Antifungal chemical compounds identified using a C. elegans pathogenicity assay.
Authors: Authors: Breger J, Fuchs BB, Aperis G, Moy TI, Ausubel FM, Mylonakis E.
PLoS Pathog
View full abstract on Pubmed
PLoS Pathog
View full abstract on Pubmed
Prospects for plant-derived antibacterials.
p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans.
Authors: Authors: Troemel ER, Chu SW, Reinke V, Lee SS, Ausubel FM, Kim DH.
PLoS Genet
View full abstract on Pubmed
PLoS Genet
View full abstract on Pubmed
Conjugating berberine to a multidrug efflux pump inhibitor creates an effective antimicrobial.
Authors: Authors: Ball AR, Casadei G, Samosorn S, Bremner JB, Ausubel FM, Moy TI, Lewis K.
ACS Chem Biol
View full abstract on Pubmed
ACS Chem Biol
View full abstract on Pubmed