The Ausubel laboratory uses genetic, genomic, and chemical genetic approaches to: (1) elucidate the molecular basis of microbial pathogenesis in the bacterial pathogens Pseudomonas aeruginosa and Pseudomonas syringae and (2) identify the components of the signaling pathways involved in the host innate immune response in the plant Arabidopsis thaliana and the nematode Caenorhabditis elegans.
Peroxidase-dependent apoplastic oxidative burst in Arabidopsis required for pathogen resistance.
Authors: Authors: Bindschedler LV, Dewdney J, Blee KA, Stone JM, Asai T, Plotnikov J, Denoux C, Hayes T, Gerrish C, Davies DR, Ausubel FM, Bolwell GP.
Plant J
View full abstract on Pubmed
Plant J
View full abstract on Pubmed
Identification of novel antimicrobials using a live-animal infection model.
Authors: Authors: Moy TI, Ball AR, Anklesaria Z, Casadei G, Lewis K, Ausubel FM.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Proc Natl Acad Sci U S A
View full abstract on Pubmed
An ordered, nonredundant library of Pseudomonas aeruginosa strain PA14 transposon insertion mutants.
Authors: Authors: Liberati NT, Urbach JM, Miyata S, Lee DG, Drenkard E, Wu G, Villanueva J, Wei T, Ausubel FM.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3'-5')-cyclic-GMP in virulence.
Authors: Authors: Kulasakara H, Lee V, Brencic A, Liberati N, Urbach J, Miyata S, Lee DG, Neely AN, Hyodo M, Hayakawa Y, Ausubel FM, Lory S.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial.
Authors: Authors: Lee DG, Urbach JM, Wu G, Liberati NT, Feinbaum RL, Miyata S, Diggins LT, He J, Saucier M, Déziel E, Friedman L, Li L, Grills G, Montgomery K, Kucherlapati R, Rahme LG, Ausubel FM.
Genome Biol
View full abstract on Pubmed
Genome Biol
View full abstract on Pubmed
Prevention and control of pests and diseases.
Are innate immune signaling pathways in plants and animals conserved?
RESISTANCE TO FUSARIUM OXYSPORUM 1, a dominant Arabidopsis disease-resistance gene, is not race specific.
Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis.
Authors: Authors: Mylonakis E, Moreno R, El Khoury JB, Idnurm A, Heitman J, Calderwood SB, Ausubel FM, Diener A.
Infect Immun
View full abstract on Pubmed
Infect Immun
View full abstract on Pubmed
A high-throughput, near-saturating screen for type III effector genes from Pseudomonas syringae.
Authors: Authors: Chang JH, Urbach JM, Law TF, Arnold LW, Hu A, Gombar S, Grant SR, Ausubel FM, Dangl JL.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Proc Natl Acad Sci U S A
View full abstract on Pubmed