The Ausubel laboratory uses genetic, genomic, and chemical genetic approaches to: (1) elucidate the molecular basis of microbial pathogenesis in the bacterial pathogens Pseudomonas aeruginosa and Pseudomonas syringae and (2) identify the components of the signaling pathways involved in the host innate immune response in the plant Arabidopsis thaliana and the nematode Caenorhabditis elegans.
Conjugating berberine to a multidrug efflux pump inhibitor creates an effective antimicrobial.
Authors: Authors: Ball AR, Casadei G, Samosorn S, Bremner JB, Ausubel FM, Moy TI, Lewis K.
ACS Chem Biol
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ACS Chem Biol
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Peroxidase-dependent apoplastic oxidative burst in Arabidopsis required for pathogen resistance.
Authors: Authors: Bindschedler LV, Dewdney J, Blee KA, Stone JM, Asai T, Plotnikov J, Denoux C, Hayes T, Gerrish C, Davies DR, Ausubel FM, Bolwell GP.
Plant J
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Plant J
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Identification of novel antimicrobials using a live-animal infection model.
Authors: Authors: Moy TI, Ball AR, Anklesaria Z, Casadei G, Lewis K, Ausubel FM.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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An ordered, nonredundant library of Pseudomonas aeruginosa strain PA14 transposon insertion mutants.
Authors: Authors: Liberati NT, Urbach JM, Miyata S, Lee DG, Drenkard E, Wu G, Villanueva J, Wei T, Ausubel FM.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3'-5')-cyclic-GMP in virulence.
Authors: Authors: Kulasakara H, Lee V, Brencic A, Liberati N, Urbach J, Miyata S, Lee DG, Neely AN, Hyodo M, Hayakawa Y, Ausubel FM, Lory S.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Prevention and control of pests and diseases.
Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial.
Authors: Authors: Lee DG, Urbach JM, Wu G, Liberati NT, Feinbaum RL, Miyata S, Diggins LT, He J, Saucier M, Déziel E, Friedman L, Li L, Grills G, Montgomery K, Kucherlapati R, Rahme LG, Ausubel FM.
Genome Biol
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Genome Biol
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Are innate immune signaling pathways in plants and animals conserved?
RESISTANCE TO FUSARIUM OXYSPORUM 1, a dominant Arabidopsis disease-resistance gene, is not race specific.
Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis.
Authors: Authors: Mylonakis E, Moreno R, El Khoury JB, Idnurm A, Heitman J, Calderwood SB, Ausubel FM, Diener A.
Infect Immun
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Infect Immun
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