The Ausubel laboratory uses genetic, genomic, and chemical genetic approaches to: (1) elucidate the molecular basis of microbial pathogenesis in the bacterial pathogens Pseudomonas aeruginosa and Pseudomonas syringae and (2) identify the components of the signaling pathways involved in the host innate immune response in the plant Arabidopsis thaliana and the nematode Caenorhabditis elegans.
Mediation of pathogen resistance by exudation of antimicrobials from roots.
Authors: Authors: Bais HP, Prithiviraj B, Jha AK, Ausubel FM, Vivanco JM.
Nature
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Nature
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Evolutionary perspectives on innate immunity from the study of Caenorhabditis elegans.
Staphylococcus aureus virulence factors identified by using a high-throughput Caenorhabditis elegans-killing model.
Authors: Authors: Begun J, Sifri CD, Goldman S, Calderwood SB, Ausubel FM.
Infect Immun
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Infect Immun
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Pseudomonas syringae manipulates systemic plant defenses against pathogens and herbivores.
Authors: Authors: Cui J, Bahrami AK, Pringle EG, Hernandez-Guzman G, Bender CL, Pierce NE, Ausubel FM.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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The worm has turned--microbial virulence modeled in Caenorhabditis elegans.
VPEgamma exhibits a caspase-like activity that contributes to defense against pathogens.
Authors: Authors: Rojo E, Martín R, Carter C, Zouhar J, Pan S, Plotnikova J, Jin H, Paneque M, Sánchez-Serrano JJ, Baker B, Ausubel FM, Raikhel NV.
Curr Biol
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Curr Biol
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Construction of an Enterococcus faecalis Tn917-mediated-gene-disruption library offers insight into Tn917 insertion patterns.
Authors: Authors: Garsin DA, Urbach J, Huguet-Tapia JC, Peters JE, Ausubel FM.
J Bacteriol
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J Bacteriol
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Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals.
Authors: Authors: Mylonakis E, Idnurm A, Moreno R, El Khoury J, Rottman JB, Ausubel FM, Heitman J, Calderwood SB.
Mol Microbiol
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Mol Microbiol
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Cytotoxicity of hydrogen peroxide produced by Enterococcus faecium.
Authors: Authors: Moy TI, Mylonakis E, Calderwood SB, Ausubel FM.
Infect Immun
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Infect Immun
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Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase.
Authors: Authors: Kim DH, Liberati NT, Mizuno T, Inoue H, Hisamoto N, Matsumoto K, Ausubel FM.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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