The Ausubel laboratory uses genetic, genomic, and chemical genetic approaches to: (1) elucidate the molecular basis of microbial pathogenesis in the bacterial pathogens Pseudomonas aeruginosa and Pseudomonas syringae and (2) identify the components of the signaling pathways involved in the host innate immune response in the plant Arabidopsis thaliana and the nematode Caenorhabditis elegans.
Caenorhabditis elegans-based screen identifies Salmonella virulence factors required for conserved host-pathogen interactions.
Authors: Authors: Tenor JL, McCormick BA, Ausubel FM, Aballay A.
Curr Biol
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Curr Biol
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The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response.
Authors: Authors: Mizuno T, Hisamoto N, Terada T, Kondo T, Adachi M, Nishida E, Kim DH, Ausubel FM, Matsumoto K.
EMBO J
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EMBO J
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Contribution of gelatinase, serine protease, and fsr to the pathogenesis of Enterococcus faecalis endophthalmitis.
Authors: Authors: Engelbert M, Mylonakis E, Ausubel FM, Calderwood SB, Gilmore MS.
Infect Immun
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Infect Immun
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Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response.
Authors: Authors: Liberati NT, Fitzgerald KA, Kim DH, Feinbaum R, Golenbock DT, Ausubel FM.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response.
Authors: Authors: Apidianakis Y, Rahme LG, Heitman J, Ausubel FM, Calderwood SB, Mylonakis E.
Eukaryot Cell
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Eukaryot Cell
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Arabidopsis local resistance to Botrytis cinerea involves salicylic acid and camalexin and requires EDS4 and PAD2, but not SID2, EDS5 or PAD4.
Authors: Authors: Ferrari S, Plotnikova JM, De Lorenzo G, Ausubel FM.
Plant J
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Plant J
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Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens.
Authors: Authors: Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM.
Science
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Science
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The art of serendipity: killing of Caenorhabditis elegans by human pathogens as a model of bacterial and fungal pathogenesis.
Authors: Authors: Mylonakis E, Ausubel FM, Tang RJ, Calderwood SB.
Expert Rev Anti Infect Ther
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Expert Rev Anti Infect Ther
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Use of the Galleria mellonella caterpillar as a model host to study the role of the type III secretion system in Pseudomonas aeruginosa pathogenesis.
Authors: Authors: Miyata S, Casey M, Frank DW, Ausubel FM, Drenkard E.
Infect Immun
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Infect Immun
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Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesis.
Authors: Authors: Sifri CD, Begun J, Ausubel FM, Calderwood SB.
Infect Immun
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Infect Immun
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