The Ausubel laboratory uses genetic, genomic, and chemical genetic approaches to: (1) elucidate the molecular basis of microbial pathogenesis in the bacterial pathogens Pseudomonas aeruginosa and Pseudomonas syringae and (2) identify the components of the signaling pathways involved in the host innate immune response in the plant Arabidopsis thaliana and the nematode Caenorhabditis elegans.
Hypersusceptibility of cystic fibrosis mice to chronic Pseudomonas aeruginosa oropharyngeal colonization and lung infection.
Authors: Authors: Coleman FT, Mueschenborn S, Meluleni G, Ray C, Carey VJ, Vargas SO, Cannon CL, Ausubel FM, Pier GB.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Five components of the ethylene-response pathway identified in a screen for weak ethylene-insensitive mutants in Arabidopsis.
Authors: Authors: Alonso JM, Stepanova AN, Solano R, Wisman E, Ferrari S, Ausubel FM, Ecker JR.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Caenorhabditis elegans innate immune response triggered by Salmonella enterica requires intact LPS and is mediated by a MAPK signaling pathway.
Authors: Authors: Aballay A, Drenkard E, Hilbun LR, Ausubel FM.
Curr Biol
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Curr Biol
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Tandemly duplicated Arabidopsis genes that encode polygalacturonase-inhibiting proteins are regulated coordinately by different signal transduction pathways in response to fungal infection.
Authors: Authors: Ferrari S, Vairo D, Ausubel FM, Cervone F, De Lorenzo G.
Plant Cell
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Plant Cell
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Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis.
Authors: Authors: Mylonakis E, Ausubel FM, Perfect JR, Heitman J, Calderwood SB.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Virulence effect of Enterococcus faecalis protease genes and the quorum-sensing locus fsr in Caenorhabditis elegans and mice.
Authors: Authors: Sifri CD, Mylonakis E, Singh KV, Qin X, Garsin DA, Murray BE, Ausubel FM, Calderwood SB.
Infect Immun
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Infect Immun
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The Enterococcus faecalis fsrB gene, a key component of the fsr quorum-sensing system, is associated with virulence in the rabbit endophthalmitis model.
Authors: Authors: Mylonakis E, Engelbert M, Qin X, Sifri CD, Murray BE, Ausubel FM, Gilmore MS, Calderwood SB.
Infect Immun
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Infect Immun
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A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity.
Authors: Authors: Kim DH, Feinbaum R, Alloing G, Emerson FE, Garsin DA, Inoue H, Tanaka-Hino M, Hisamoto N, Matsumoto K, Tan MW, Ausubel FM.
Science
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Science
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Arabidopsis functional genomics.
Signals involved in Arabidopsis resistance to Trichoplusia ni caterpillars induced by virulent and avirulent strains of the phytopathogen Pseudomonas syringae.
Authors: Authors: Cui J, Jander G, Racki LR, Kim PD, Pierce NE, Ausubel FM.
Plant Physiol
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Plant Physiol
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