The Ausubel laboratory uses genetic, genomic, and chemical genetic approaches to: (1) elucidate the molecular basis of microbial pathogenesis in the bacterial pathogens Pseudomonas aeruginosa and Pseudomonas syringae and (2) identify the components of the signaling pathways involved in the host innate immune response in the plant Arabidopsis thaliana and the nematode Caenorhabditis elegans.
Fumonisin B1-induced cell death in arabidopsis protoplasts requires jasmonate-, ethylene-, and salicylate-dependent signaling pathways.
Authors: Authors: Asai T, Stone JM, Heard JE, Kovtun Y, Yorgey P, Sheen J, Ausubel FM.
Plant Cell
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Plant Cell
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Isolation and characterization of disease resistance gene homologues from rice cultivar IR64.
Authors: Authors: Ilag LL, Yadav RC, Huang N, Ronald PC, Ausubel FM.
Gene
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Gene
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Elucidating the molecular mechanisms of bacterial virulence using non-mammalian hosts.
Authors: Authors: Mahajan-Miklos S, Rahme LG, Ausubel FM.
Mol Microbiol
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Mol Microbiol
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Pathogens and hosts: the dance is the same, the couples are different.
Authors: Authors: Keen N, Staskawicz B, Mekalanos J, Ausubel F, Cook RJ.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Plants and animals share functionally common bacterial virulence factors.
Authors: Authors: Rahme LG, Ausubel FM, Cao H, Drenkard E, Goumnerov BC, Lau GW, Mahajan-Miklos S, Plotnikova J, Tan MW, Tsongalis J, Walendziewicz CL, Tompkins RG.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Positive correlation between virulence of Pseudomonas aeruginosa mutants in mice and insects.
The alternative sigma factor RpoN is required for hrp activity in Pseudomonas syringae pv. maculicola and acts at the level of hrpL transcription.
Virulence of the phytopathogen Pseudomonas syringae pv. maculicola is rpoN dependent.
Authors: Authors: Hendrickson EL, Guevera P, Peñaloza-Vàzquez A, Shao J, Bender C, Ausubel FM.
J Bacteriol
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J Bacteriol
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Caenorhabditis elegans: a model genetic host to study Pseudomonas aeruginosa pathogenesis.
Arabidopsis thaliana PAD4 encodes a lipase-like gene that is important for salicylic acid signaling.
Authors: Authors: Jirage D, Tootle TL, Reuber TL, Frost LN, Feys BJ, Parker JE, Ausubel FM, Glazebrook J.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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