The Ausubel laboratory uses genetic, genomic, and chemical genetic approaches to: (1) elucidate the molecular basis of microbial pathogenesis in the bacterial pathogens Pseudomonas aeruginosa and Pseudomonas syringae and (2) identify the components of the signaling pathways involved in the host innate immune response in the plant Arabidopsis thaliana and the nematode Caenorhabditis elegans.
Use of model plant hosts to identify Pseudomonas aeruginosa virulence factors.
Authors: Authors: Rahme LG, Tan MW, Le L, Wong SM, Tompkins RG, Calderwood SB, Ausubel FM.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Inactivation of the alpha C protein antigen gene, bca, by a novel shuttle/suicide vector results in attenuation of virulence and immunity in group B Streptococcus.
Authors: Authors: Li J, Kasper DL, Ausubel FM, Rosner B, Michel JL.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Phytoalexin-deficient mutants of Arabidopsis reveal that PAD4 encodes a regulatory factor and that four PAD genes contribute to downy mildew resistance.
Authors: Authors: Glazebrook J, Zook M, Mert F, Kagan I, Rogers EE, Crute IR, Holub EB, Hammerschmidt R, Ausubel FM.
Genetics
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Genetics
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Arabidopsis enhanced disease susceptibility mutants exhibit enhanced susceptibility to several bacterial pathogens and alterations in PR-1 gene expression.
Use of Arabidopsis for genetic dissection of plant defense responses.
Molecular recognition of pathogen attack occurs inside of plant cells in plant disease resistance specified by the Arabidopsis genes RPS2 and RPM1.
Authors: Authors: Leister RT, Ausubel FM, Katagiri F.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Mode of action of the Arabidopsis thaliana phytoalexin camalexin and its role in Arabidopsis-pathogen interactions.
Authors: Authors: Rogers EE, Glazebrook J, Ausubel FM.
Mol Plant Microbe Interact
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Mol Plant Microbe Interact
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Use of cleaved amplified polymorphic sequences to distinguish strains of Staphylococcus epidermidis.
Authors: Authors: Calderwood SB, Baker MA, Carroll PA, Michel JL, Arbeit RD, Ausubel FM.
J Clin Microbiol
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J Clin Microbiol
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Isolation of Arabidopsis mutants with enhanced disease susceptibility by direct screening.
Isolation of Arabidopsis genes that differentiate between resistance responses mediated by the RPS2 and RPM1 disease resistance genes.