The Ausubel laboratory uses genetic, genomic, and chemical genetic approaches to: (1) elucidate the molecular basis of microbial pathogenesis in the bacterial pathogens Pseudomonas aeruginosa and Pseudomonas syringae and (2) identify the components of the signaling pathways involved in the host innate immune response in the plant Arabidopsis thaliana and the nematode Caenorhabditis elegans.
Nitrogen fixation specific regulatory genes of Klebsiella pneumoniae and Rhizobium meliloti share homology with the general nitrogen regulatory gene ntrC of K. pneumoniae.
Authors: Authors: Buikema WJ, Szeto WW, Lemley PV, Orme-Johnson WH, Ausubel FM.
Nucleic Acids Res
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Nucleic Acids Res
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Nodule-specific polypeptides from effective alfalfa root nodules and from ineffective nodules lacking nitrogenase.
Symbiotic nitrogen fixation: developmental genetics of nodule formation.
Authors: Authors: Lang-Unnasch N, Dunn K, Ausubel FM.
Cold Spring Harb Symp Quant Biol
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Cold Spring Harb Symp Quant Biol
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Rhizobium meliloti nodulation genes allow Agrobacterium tumefaciens and Escherichia coli to form pseudonodules on alfalfa.
Authors: Authors: Hirsch AM, Wilson KJ, Jones JD, Bang M, Walker VV, Ausubel FM.
J Bacteriol
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J Bacteriol
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Regulation of nitrogen fixation genes.
A Rhizobium meliloti symbiotic regulatory gene.
Authors: Authors: Szeto WW, Zimmerman JL, Sundaresan V, Ausubel FM.
Cell
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Cell
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Mutations affecting regulation of the Klebsiella pneumoniae nifH (nitrogenase reductase) promotor.
Molecular characterization of Tn5-induced symbiotic (Fix-) mutants of Rhizobium meliloti.
Conditionally replicating plasmid vectors that can integrate into the Klebsiella pneumoniae chromosome via bacteriophage P4 site-specific recombination.
Ultrastructural analysis of ineffective alfalfa nodules formed by nif::Tn5 mutants of Rhizobium meliloti.