The Ausubel laboratory uses genetic, genomic, and chemical genetic approaches to: (1) elucidate the molecular basis of microbial pathogenesis in the bacterial pathogens Pseudomonas aeruginosa and Pseudomonas syringae and (2) identify the components of the signaling pathways involved in the host innate immune response in the plant Arabidopsis thaliana and the nematode Caenorhabditis elegans.
Associations with rhizosphere bacteria can confer an adaptive advantage to plants.
Associations with rhizosphere bacteria can confer an adaptive advantage to plants.
Jasmonate signalling in Arabidopsis involves SGT1b-HSP70-HSP90 chaperone complexes.
Authors: Authors: Zhang XC, Millet YA, Cheng Z, Bush J, Ausubel FM.
Nat Plants
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Nat Plants
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On the Mechanism of Berberine-INF55 (5-Nitro-2-phenylindole) Hybrid Antibacterials.
Authors: Authors: Dolla NK, Chen C, Larkins-Ford J, Rajamuthiah R, Jagadeesan S, Conery AL, Ausubel FM, Mylonakis E, Bremner JB, Lewis K, Kelso MJ.
Aust J Chem
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Aust J Chem
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Repurposing salicylanilide anthelmintic drugs to combat drug resistant Staphylococcus aureus.
Authors: Authors: Rajamuthiah R, Fuchs BB, Conery AL, Kim W, Jayamani E, Kwon B, Ausubel FM, Mylonakis E.
PLoS One
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PLoS One
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A Defensin from the Model Beetle Tribolium castaneum Acts Synergistically with Telavancin and Daptomycin against Multidrug Resistant Staphylococcus aureus.
Authors: Authors: Rajamuthiah R, Jayamani E, Conery AL, Fuchs BB, Kim W, Johnston T, Vilcinskas A, Ausubel FM, Mylonakis E.
PLoS One
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PLoS One
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Identification of an Antimicrobial Agent Effective against Methicillin-Resistant Staphylococcus aureus Persisters Using a Fluorescence-Based Screening Strategy.
Authors: Authors: Kim W, Conery AL, Rajamuthiah R, Fuchs BB, Ausubel FM, Mylonakis E.
PLoS One
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PLoS One
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Next-Gen Sequencing-Based Mapping and Identification of Ethyl Methanesulfonate-Induced Mutations in Arabidopsis thaliana.
Authors: Authors: Zhang XC, Millet Y, Ausubel FM, Borowsky M.
Curr Protoc Mol Biol
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Curr Protoc Mol Biol
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Twists and turns: my career path and concerns about the future.
The evolutionarily conserved mediator subunit MDT-15/MED15 links protective innate immune responses and xenobiotic detoxification.
Authors: Authors: Pukkila-Worley R, Feinbaum RL, McEwan DL, Conery AL, Ausubel FM.
PLoS Pathog
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PLoS Pathog
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