The Ausubel laboratory uses genetic, genomic, and chemical genetic approaches to: (1) elucidate the molecular basis of microbial pathogenesis in the bacterial pathogens Pseudomonas aeruginosa and Pseudomonas syringae and (2) identify the components of the signaling pathways involved in the host innate immune response in the plant Arabidopsis thaliana and the nematode Caenorhabditis elegans.
The evolutionarily conserved mediator subunit MDT-15/MED15 links protective innate immune responses and xenobiotic detoxification.
Authors: Authors: Pukkila-Worley R, Feinbaum RL, McEwan DL, Conery AL, Ausubel FM.
PLoS Pathog
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PLoS Pathog
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High-throughput screening for novel anti-infectives using a C. elegans pathogenesis model.
Authors: Authors: Conery AL, Larkins-Ford J, Ausubel FM, Kirienko NV.
Curr Protoc Chem Biol
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Curr Protoc Chem Biol
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Enterococcus infection biology: lessons from invertebrate host models.
Whole animal automated platform for drug discovery against multi-drug resistant Staphylococcus aureus.
Authors: Authors: Rajamuthiah R, Fuchs BB, Jayamani E, Kim Y, Larkins-Ford J, Conery A, Ausubel FM, Mylonakis E.
PLoS One
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PLoS One
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Pseudomonas aeruginosa PA14 pathogenesis in Caenorhabditis elegans.
Authors: Authors: Kirienko NV, Cezairliyan BO, Ausubel FM, Powell JR.
Methods Mol Biol
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Methods Mol Biol
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Virulence profile: Frederick M Ausubel.
Pathogen-triggered ethylene signaling mediates systemic-induced susceptibility to herbivory in Arabidopsis.
Authors: Authors: Groen SC, Whiteman NK, Bahrami AK, Wilczek AM, Cui J, Russell JA, Cibrian-Jaramillo A, Butler IA, Rana JD, Huang GH, Bush J, Ausubel FM, Pierce NE.
Plant Cell
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Plant Cell
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Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death.
Authors: Authors: Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM.
Cell Host Microbe
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Cell Host Microbe
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Trehalose biosynthesis promotes Pseudomonas aeruginosa pathogenicity in plants.
Authors: Authors: Djonovic S, Urbach JM, Drenkard E, Bush J, Feinbaum R, Ausubel JL, Traficante D, Risech M, Kocks C, Fischbach MA, Priebe GP, Ausubel FM.
PLoS Pathog
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PLoS Pathog
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Identification of Pseudomonas aeruginosa phenazines that kill Caenorhabditis elegans.
Authors: Authors: Cezairliyan B, Vinayavekhin N, Grenfell-Lee D, Yuen GJ, Saghatelian A, Ausubel FM.
PLoS Pathog
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PLoS Pathog
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