The Ausubel laboratory uses genetic, genomic, and chemical genetic approaches to: (1) elucidate the molecular basis of microbial pathogenesis in the bacterial pathogens Pseudomonas aeruginosa and Pseudomonas syringae and (2) identify the components of the signaling pathways involved in the host innate immune response in the plant Arabidopsis thaliana and the nematode Caenorhabditis elegans.
Perception of volatiles produced by UVC-irradiated plants alters the response to viral infection in naïve neighboring plants.
Authors: Authors: Yao Y, Danna CH, Ausubel FM, Kovalchuk I.
Plant Signal Behav
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Plant Signal Behav
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An image analysis toolbox for high-throughput C. elegans assays.
Authors: Authors: Wählby C, Kamentsky L, Liu ZH, Riklin-Raviv T, Conery AL, O'Rourke EJ, Sokolnicki KL, Visvikis O, Ljosa V, Irazoqui JE, Golland P, Ruvkun G, Ausubel FM, Carpenter AE.
Nat Methods
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Nat Methods
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Host translational inhibition by Pseudomonas aeruginosa Exotoxin A Triggers an immune response in Caenorhabditis elegans.
Authors: Authors: McEwan DL, Kirienko NV, Ausubel FM.
Cell Host Microbe
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Cell Host Microbe
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A peroxidase-dependent apoplastic oxidative burst in cultured Arabidopsis cells functions in MAMP-elicited defense.
Authors: Authors: O'Brien JA, Daudi A, Finch P, Butt VS, Whitelegge JP, Souda P, Ausubel FM, Bolwell GP.
Plant Physiol
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Plant Physiol
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Immune defense mechanisms in the Caenorhabditis elegans intestinal epithelium.
Stimulation of host immune defenses by a small molecule protects C. elegans from bacterial infection.
Authors: Authors: Pukkila-Worley R, Feinbaum R, Kirienko NV, Larkins-Ford J, Conery AL, Ausubel FM.
PLoS Genet
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PLoS Genet
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Genome-wide identification of Pseudomonas aeruginosa virulence-related genes using a Caenorhabditis elegans infection model.
Authors: Authors: Feinbaum RL, Urbach JM, Liberati NT, Djonovic S, Adonizio A, Carvunis AR, Ausubel FM.
PLoS Pathog
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PLoS Pathog
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The apoplastic oxidative burst peroxidase in Arabidopsis is a major component of pattern-triggered immunity.
Authors: Authors: Daudi A, Cheng Z, O'Brien JA, Mammarella N, Khan S, Ausubel FM, Bolwell GP.
Plant Cell
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Plant Cell
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Genes involved in the evolution of herbivory by a leaf-mining, Drosophilid fly.
Authors: Authors: Whiteman NK, Gloss AD, Sackton TB, Groen SC, Humphrey PT, Lapoint RT, Sønderby IE, Halkier BA, Kocks C, Ausubel FM, Pierce NE.
Genome Biol Evol
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Genome Biol Evol
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Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model.
Authors: Authors: Limmer S, Haller S, Drenkard E, Lee J, Yu S, Kocks C, Ausubel FM, Ferrandon D.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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