The Ausubel laboratory uses genetic, genomic, and chemical genetic approaches to: (1) elucidate the molecular basis of microbial pathogenesis in the bacterial pathogens Pseudomonas aeruginosa and Pseudomonas syringae and (2) identify the components of the signaling pathways involved in the host innate immune response in the plant Arabidopsis thaliana and the nematode Caenorhabditis elegans.
99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: Caenorhabditis elegans as a model to study tissues involved in host immunity and microbial pathogenesis.
bZIP transcription factor zip-2 mediates an early response to Pseudomonas aeruginosa infection in Caenorhabditis elegans.
Authors: Authors: Estes KA, Dunbar TL, Powell JR, Ausubel FM, Troemel ER.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Innate immune responses activated in Arabidopsis roots by microbe-associated molecular patterns.
Authors: Authors: Millet YA, Danna CH, Clay NK, Songnuan W, Simon MD, Werck-Reichhart D, Ausubel FM.
Plant Cell
View full abstract on Pubmed
Plant Cell
View full abstract on Pubmed
Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates.
Morphology-guided graph search for untangling objects: C. elegans analysis.
Authors: Authors: Raviv TR, Ljosa V, Conery AL, Ausubel FM, Carpenter AE, Golland P, Wählby C.
Med Image Comput Comput Assist Interv
View full abstract on Pubmed
Med Image Comput Comput Assist Interv
View full abstract on Pubmed
Identification of antifungal compounds active against Candida albicans using an improved high-throughput Caenorhabditis elegans assay.
Authors: Authors: Okoli I, Coleman JJ, Tampakakis E, Tempakakis E, An WF, Holson E, Wagner F, Conery AL, Larkins-Ford J, Wu G, Stern A, Ausubel FM, Mylonakis E.
PLoS One
View full abstract on Pubmed
PLoS One
View full abstract on Pubmed
High-throughput screen for novel antimicrobials using a whole animal infection model.
Authors: Authors: Moy TI, Conery AL, Larkins-Ford J, Wu G, Mazitschek R, Casadei G, Lewis K, Carpenter AE, Ausubel FM.
ACS Chem Biol
View full abstract on Pubmed
ACS Chem Biol
View full abstract on Pubmed
Using PATIMDB to create bacterial transposon insertion mutant libraries.
Authors: Authors: Urbach JM, Wei T, Liberati N, Grenfell-Lee D, Villanueva J, Wu G, Ausubel FM.
Curr Protoc Mol Biol
View full abstract on Pubmed
Curr Protoc Mol Biol
View full abstract on Pubmed
The G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response.
Authors: Authors: Powell JR, Kim DH, Ausubel FM.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Temporal global expression data reveal known and novel salicylate-impacted processes and regulators mediating powdery mildew growth and reproduction on Arabidopsis.
Authors: Authors: Chandran D, Tai YC, Hather G, Dewdney J, Denoux C, Burgess DG, Ausubel FM, Speed TP, Wildermuth MC.
Plant Physiol
View full abstract on Pubmed
Plant Physiol
View full abstract on Pubmed