The Ausubel laboratory uses genetic, genomic, and chemical genetic approaches to: (1) elucidate the molecular basis of microbial pathogenesis in the bacterial pathogens Pseudomonas aeruginosa and Pseudomonas syringae and (2) identify the components of the signaling pathways involved in the host innate immune response in the plant Arabidopsis thaliana and the nematode Caenorhabditis elegans.
Glucosinolate metabolites required for an Arabidopsis innate immune response.
Authors: Authors: Clay NK, Adio AM, Denoux C, Jander G, Ausubel FM.
Science
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Science
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Microsporidia are natural intracellular parasites of the nematode Caenorhabditis elegans.
Authors: Authors: Troemel ER, Félix MA, Whiteman NK, Barrière A, Ausubel FM.
PLoS Biol
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PLoS Biol
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Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions.
Authors: Authors: Irazoqui JE, Ng A, Xavier RJ, Ausubel FM.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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The AtrbohD-mediated oxidative burst elicited by oligogalacturonides in Arabidopsis is dispensable for the activation of defense responses effective against Botrytis cinerea.
Authors: Authors: Galletti R, Denoux C, Gambetta S, Dewdney J, Ausubel FM, De Lorenzo G, Ferrari S.
Plant Physiol
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Plant Physiol
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Attenuation of Pseudomonas aeruginosa virulence by medicinal plants in a Caenorhabditis elegans model system.
Authors: Authors: Adonizio A, Leal SM, Ausubel FM, Mathee K.
J Med Microbiol
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J Med Microbiol
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Animal models for host-pathogen interactions.
Activation of defense response pathways by OGs and Flg22 elicitors in Arabidopsis seedlings.
Authors: Authors: Denoux C, Galletti R, Mammarella N, Gopalan S, Werck D, De Lorenzo G, Ferrari S, Ausubel FM, Dewdney J.
Mol Plant
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Mol Plant
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DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans.
A metasystem of framework model organisms to study emergence of new host-microbe adaptations.
Comparing insertion libraries in two Pseudomonas aeruginosa strains to assess gene essentiality.
Authors: Authors: Liberati NT, Urbach JM, Thurber TK, Wu G, Ausubel FM.
Methods Mol Biol
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Methods Mol Biol
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