Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital
Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Antigen Presentation by CD1 Lipids, T Cells, and NKT Cells in Microbial Immunity.
Authors: Authors: Cohen NR, Garg S, Brenner MB.
Adv Immunol
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Innate invariant NKT cells recognize Mycobacterium tuberculosis-infected macrophages, produce interferon-gamma, and kill intracellular bacteria.
Authors: Authors: Sada-Ovalle I, Chiba A, Gonzales A, Brenner MB, Behar SM.
PLoS Pathog
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Serum lipids regulate dendritic cell CD1 expression and function.
Authors: Authors: Leslie DS, Dascher CC, Cembrola K, Townes MA, Hava DL, Hugendubler LC, Mueller E, Fox L, Roura-Mir C, Moody DB, Vincent MS, Gumperz JE, Illarionov PA, Besra GS, Reynolds CG, Brenner MB.
Immunology
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CD1a and MHC class I follow a similar endocytic recycling pathway.
Authors: Authors: Barral DC, Cavallari M, McCormick PJ, Garg S, Magee AI, Bonifacino JS, De Libero G, Brenner MB.
Traffic
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Rapid NKT cell responses are self-terminating during the course of microbial infection.
Authors: Authors: Chiba A, Dascher CC, Besra GS, Brenner MB.
J Immunol
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Evasion of peptide, but not lipid antigen presentation, through pathogen-induced dendritic cell maturation.
Authors: Authors: Hava DL, van der Wel N, Cohen N, Dascher CC, Houben D, León L, Agarwal S, Sugita M, van Zon M, Kent SC, Shams H, Peters PJ, Brenner MB.
Proc Natl Acad Sci U S A
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Microsomal triglyceride transfer protein regulates endogenous and exogenous antigen presentation by group 1 CD1 molecules.
Authors: Authors: Kaser A, Hava DL, Dougan SK, Chen Z, Zeissig S, Brenner MB, Blumberg RS.
Eur J Immunol
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NK T cells provide lipid antigen-specific cognate help for B cells.
Authors: Authors: Leadbetter EA, Brigl M, Illarionov P, Cohen N, Luteran MC, Pillai S, Besra GS, Brenner MB.
Proc Natl Acad Sci U S A
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The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis.
Authors: Authors: Noss EH, Brenner MB.
Immunol Rev
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Coexpression of two mesenchymal cadherins, cadherin 11 and N-cadherin, on murine fibroblast-like synoviocytes.
Authors: Authors: Agarwal SK, Lee DM, Kiener HP, Brenner MB.
Arthritis Rheum
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