Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital

Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

CD1 antigen presentation: how it works.

Authors: Authors: Barral DC, Brenner MB.
Nat Rev Immunol 2007-12-01
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The crystal structure of human E-cadherin domains 1 and 2, and comparison with other cadherins in the context of adhesion mechanism.

Authors: Authors: Parisini E, Higgins JM, Liu JH, Brenner MB, Wang JH.
J Mol Biol 2007-10-19
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Cadherin-11 in synovial lining formation and pathology in arthritis.

Authors: Authors: Lee DM, Kiener HP, Agarwal SK, Noss EH, Watts GF, Chisaka O, Takeichi M, Brenner MB.
Science 2007-03-16
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Pathways of CD1 and lipid antigen delivery, trafficking, processing, loading, and presentation.

Authors: Authors: Sugita M, Barral DC, Brenner MB.
Curr Top Microbiol Immunol 2007-01-01
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Cadherin-11 induces rheumatoid arthritis fibroblast-like synoviocytes to form lining layers in vitro.

Authors: Authors: Kiener HP, Lee DM, Agarwal SK, Brenner MB.
Am J Pathol 2006-05-01
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The cadherin-11 cytoplasmic juxtamembrane domain promotes alpha-catenin turnover at adherens junctions and intercellular motility.

Authors: Authors: Kiener HP, Stipp CS, Allen PG, Higgins JM, Brenner MB.
Mol Biol Cell 2006-05-01
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Role of adhesion molecules in synovial inflammation.

Authors: Authors: Agarwal SK, Brenner MB.
Curr Opin Rheumatol 2006-05-01
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Conserved and heterogeneous lipid antigen specificities of CD1d-restricted NKT cell receptors.

Authors: Authors: Brigl M, van den Elzen P, Chen X, Meyers JH, Wu D, Wong CH, Reddington F, Illarianov PA, Besra GS, Brenner MB, Gumperz JE.
J Immunol 2006-03-15
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CD4+-T-cell effector functions and costimulatory requirements essential for surviving mucosal infection with Citrobacter rodentium.

Authors: Authors: Bry L, Brigl M, Brenner MB.
Infect Immun 2006-01-01
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CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens.

Authors: Authors: Vincent MS, Xiong X, Grant EP, Peng W, Brenner MB.
J Immunol 2005-11-15
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