Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital

Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Apolipoprotein-mediated pathways of lipid antigen presentation.

Authors: Authors: van den Elzen P, Garg S, León L, Brigl M, Leadbetter EA, Gumperz JE, Dascher CC, Cheng TY, Sacks FM, Illarionov PA, Besra GS, Kent SC, Moody DB, Brenner MB.
Nature 2005-10-06
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Characterization of two avian MHC-like genes reveals an ancient origin of the CD1 family.

Authors: Authors: Miller MM, Wang C, Parisini E, Coletta RD, Goto RM, Lee SY, Barral DC, Townes M, Roura-Mir C, Ford HL, Brenner MB, Dascher CC.
Proc Natl Acad Sci U S A 2005-06-14
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Subcellular localization of mycobacteria in tissues and detection of lipid antigens in organelles using cryo-techniques for light and electron microscopy.

Authors: Authors: van der Wel NN, Fluitsma DM, Dascher CC, Brenner MB, Peters PJ.
Curr Opin Microbiol 2005-06-01
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Manifestations of inflammatory arthritis are critically dependent on LFA-1.

Authors: Authors: Watts GM, Beurskens FJ, Martin-Padura I, Ballantyne CM, Klickstein LB, Brenner MB, Lee DM.
J Immunol 2005-03-15
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CD1 assembly and the formation of CD1-antigen complexes.

Authors: Authors: Hava DL, Brigl M, van den Elzen P, Zajonc DM, Wilson IA, Brenner MB.
Curr Opin Immunol 2005-03-01
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Molecular mechanism of lipopeptide presentation by CD1a.

Authors: Authors: Zajonc DM, Crispin MD, Bowden TA, Young DC, Cheng TY, Hu J, Costello CE, Rudd PM, Dwek RA, Miller MJ, Brenner MB, Moody DB, Wilson IA.
Immunity 2005-03-01
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Building the synovium: cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion.

Authors: Authors: Kiener HP, Brenner MB.
Arthritis Res Ther 2005-01-01
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The role of innate immunity in autoimmunity.

Authors: Authors: Bach JF, Bendelac A, Brenner MB, Cantor H, De Libero G, Kronenberg M, Lanier LL, Raulet DH, Shlomchik MJ, von Herrath MG.
J Exp Med 2004-12-20
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Cadherin-11 provides specific cellular adhesion between fibroblast-like synoviocytes.

Authors: Authors: Valencia X, Higgins JM, Kiener HP, Lee DM, Podrebarac TA, Dascher CC, Watts GF, Mizoguchi E, Simmons B, Patel DD, Bhan AK, Brenner MB.
J Exp Med 2004-12-20
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Identification of guinea pig gammadelta T cells and characterization during pulmonary tuberculosis.

Authors: Authors: Xiong X, Morita CT, Bukowski JF, Brenner MB, Dascher CC.
Vet Immunol Immunopathol 2004-11-01
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