Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital

Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Regulation of tumor necrosis factor alpha gene expression by mycobacteria involves the assembly of a unique enhanceosome dependent on the coactivator proteins CBP/p300.

Authors: Authors: Barthel R, Tsytsykova AV, Barczak AK, Tsai EY, Dascher CC, Brenner MB, Goldfeld AE.
Mol Cell Biol 2003-01-01
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CD1-mediated gamma/delta T cell maturation of dendritic cells.

Authors: Authors: Leslie DS, Vincent MS, Spada FM, Das H, Sugita M, Morita CT, Brenner MB.
J Exp Med 2002-12-16
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Conservation of CD1 intracellular trafficking patterns between mammalian species.

Authors: Authors: Dascher CC, Hiromatsu K, Xiong X, Sugita M, Buhlmann JE, Dodge IL, Lee SY, Roura-Mir C, Watts GF, Roy CJ, Behar SM, Clemens DL, Porcelli SA, Brenner MB.
J Immunol 2002-12-15
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CD1-dependent dendritic cell instruction.

Authors: Authors: Vincent MS, Leslie DS, Gumperz JE, Xiong X, Grant EP, Brenner MB.
Nat Immunol 2002-12-01
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CD1 molecules efficiently present antigen in immature dendritic cells and traffic independently of MHC class II during dendritic cell maturation.

Authors: Authors: Cao X, Sugita M, Van Der Wel N, Lai J, Rogers RA, Peters PJ, Brenner MB.
J Immunol 2002-11-01
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Mast cells: a cellular link between autoantibodies and inflammatory arthritis.

Authors: Authors: Lee DM, Friend DS, Gurish MF, Benoist C, Mathis D, Brenner MB.
Science 2002-09-06
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Induction of CD1-restricted immune responses in guinea pigs by immunization with mycobacterial lipid antigens.

Authors: Authors: Hiromatsu K, Dascher CC, LeClair KP, Sugita M, Furlong ST, Brenner MB, Porcelli SA.
J Immunol 2002-07-01
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Characterization of guinea-pig group 1 CD1 proteins.

Authors: Authors: Hiromatsu K, Dascher CC, Sugita M, Gingrich-Baker C, Behar SM, LeClair KP, Brenner MB, Porcelli SA.
Immunology 2002-06-01
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Failure of trafficking and antigen presentation by CD1 in AP-3-deficient cells.

Authors: Authors: Sugita M, Cao X, Watts GF, Rogers RA, Bonifacino JS, Brenner MB.
Immunity 2002-05-01
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Fine specificity of TCR complementarity-determining region residues and lipid antigen hydrophilic moieties in the recognition of a CD1-lipid complex.

Authors: Authors: Grant EP, Beckman EM, Behar SM, Degano M, Frederique D, Besra GS, Wilson IA, Porcelli SA, Furlong ST, Brenner MB.
J Immunol 2002-04-15
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