Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital

Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Adaptive immune response of Vgamma2Vdelta2+ T cells during mycobacterial infections.

Authors: Authors: Shen Y, Zhou D, Qiu L, Lai X, Simon M, Shen L, Kou Z, Wang Q, Jiang L, Estep J, Hunt R, Clagett M, Sehgal PK, Li Y, Zeng X, Morita CT, Brenner MB, Letvin NL, Chen ZW.
Science 2002-03-22
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Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining.

Authors: Authors: Gumperz JE, Miyake S, Yamamura T, Brenner MB.
J Exp Med 2002-03-04
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Influence of Mycobacterium bovis bacillus Calmette Guérin on in vitro induction of CD1 molecules in human adherent mononuclear cells.

Authors: Authors: Giuliani A, Prete SP, Graziani G, Aquino A, Balduzzi A, Sugita M, Brenner MB, Iona E, Fattorini L, Orefici G, Porcelli SA, Bonmassar E.
Infect Immun 2001-12-01
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CD1-specific T cells in microbial immunity.

Authors: Authors: Gumperz JE, Brenner MB.
Curr Opin Immunol 2001-08-01
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T lymphocyte recognition of human group 1 CD1 molecules: implications for innate and acquired immunity.

Authors: Authors: Sugita M, Brenner MB.
Semin Immunol 2000-12-01
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T cell receptor-dependent activation of human lymphocytes through cell surface ganglioside GT1b: implications for innate immunity.

Authors: Authors: Bukowski JF, Roncarolo MG, Spits H, Krangel MS, Morita CT, Brenner MB, Band H.
Eur J Immunol 2000-11-01
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Molecular recognition of human CD1b antigen complexes: evidence for a common pattern of interaction with alpha beta TCRs.

Authors: Authors: Melián A, Watts GF, Shamshiev A, De Libero G, Clatworthy A, Vincent M, Brenner MB, Behar S, Niazi K, Modlin RL, Almo S, Ostrov D, Nathenson SG, Porcelli SA.
J Immunol 2000-10-15
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CD1b-mediated T cell recognition of a glycolipid antigen generated from mycobacterial lipid and host carbohydrate during infection.

Authors: Authors: Moody DB, Guy MR, Grant E, Cheng TY, Brenner MB, Besra GS, Porcelli SA.
J Exp Med 2000-10-02
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T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines.

Authors: Authors: Agace WW, Higgins JM, Sadasivan B, Brenner MB, Parker CM.
Curr Opin Cell Biol 2000-10-01
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The role of alpha and beta chains in ligand recognition by beta 7 integrins.

Authors: Authors: Higgins JM, Cernadas M, Tan K, Irie A, Wang J, Takada Y, Brenner MB.
J Biol Chem 2000-08-18
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