Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital
Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

CD1c molecules broadly survey the endocytic system.
Authors: Authors: Sugita M, van Der Wel N, Rogers RA, Peters PJ, Brenner MB.
Proc Natl Acad Sci U S A
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Molecular basis for leukocyte integrin alpha(E)beta(7) adhesion to epithelial (E)-cadherin.
Authors: Authors: Taraszka KS, Higgins JM, Tan K, Mandelbrot DA, Wang JH, Brenner MB.
J Exp Med
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Evidence for human CD4+ T cells in the CD1-restricted repertoire: derivation of mycobacteria-reactive T cells from leprosy lesions.
Authors: Authors: Sieling PA, Ochoa MT, Jullien D, Leslie DS, Sabet S, Rosat JP, Burdick AE, Rea TH, Brenner MB, Porcelli SA, Modlin RL.
J Immunol
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CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection.
Authors: Authors: Moody DB, Ulrichs T, Mühlecker W, Young DC, Gurcha SS, Grant E, Rosat JP, Brenner MB, Costello CE, Besra GS, Porcelli SA.
Nature
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Pathways for lipid antigen presentation by CD1 molecules: nowhere for intracellular pathogens to hide.
Authors: Authors: Sugita M, Peters PJ, Brenner MB.
Traffic
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Self-recognition of CD1 by gamma/delta T cells: implications for innate immunity.
Authors: Authors: Spada FM, Grant EP, Peters PJ, Sugita M, Melián A, Leslie DS, Lee HK, van Donselaar E, Hanson DA, Krensky AM, Majdic O, Porcelli SA, Morita CT, Brenner MB.
J Exp Med
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Murine CD1d-restricted T cell recognition of cellular lipids.
Authors: Authors: Gumperz JE, Roy C, Makowska A, Lum D, Sugita M, Podrebarac T, Koezuka Y, Porcelli SA, Cardell S, Brenner MB, Behar SM.
Immunity
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Antigen recognition by human gamma delta T cells: pattern recognition by the adaptive immune system.
Authors: Authors: Morita CT, Mariuzza RA, Brenner MB.
Springer Semin Immunopathol
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IQGAP1 and calmodulin modulate E-cadherin function.
Authors: Authors: Li Z, Kim SH, Higgins JM, Brenner MB, Sacks DB.
J Biol Chem
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Separate pathways for antigen presentation by CD1 molecules.
Authors: Authors: Sugita M, Grant EP, van Donselaar E, Hsu VW, Rogers RA, Peters PJ, Brenner MB.
Immunity
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