Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital
Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Conservation of a CD1 multigene family in the guinea pig.
Authors: Authors: Dascher CC, Hiromatsu K, Naylor JW, Brauer PP, Brown KA, Storey JR, Behar SM, Kawasaki ES, Porcelli SA, Brenner MB, LeClair KP.
J Immunol
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Lymphocyte adhesion to epithelia and endothelia mediated by the lymphocyte endothelial-epithelial cell adhesion molecule glycoprotein.
Authors: Authors: Shieh CC, Sadasivan BK, Russell GJ, Schön MP, Parker CM, Brenner MB.
J Immunol
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Human gamma delta T cells recognize alkylamines derived from microbes, edible plants, and tea: implications for innate immunity.
Authors: Authors: Bukowski JF, Morita CT, Brenner MB.
Immunity
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Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis.
Authors: Authors: Behar SM, Dascher CC, Grusby MJ, Wang CR, Brenner MB.
J Exp Med
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Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice.
Authors: Authors: Schön MP, Arya A, Murphy EA, Adams CM, Strauch UG, Agace WW, Marsal J, Donohue JP, Her H, Beier DR, Olson S, Lefrancois L, Brenner MB, Grusby MJ, Parker CM.
J Immunol
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Expression of CD1d2 on thymocytes is not sufficient for the development of NK T cells in CD1d1-deficient mice.
Authors: Authors: Chen YH, Wang B, Chun T, Zhao L, Cardell S, Behar SM, Brenner MB, Wang CR.
J Immunol
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Molecular recognition of lipid antigens by T cell receptors.
Authors: Authors: Grant EP, Degano M, Rosat JP, Stenger S, Modlin RL, Wilson IA, Porcelli SA, Brenner MB.
J Exp Med
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Membrane anchoring of calnexin facilitates its interaction with its targets.
Authors: Authors: Ho SC, Rajagopalan S, Chaudhuri S, Shieh CC, Brenner MB, Pillai S.
Mol Immunol
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Diverse TCRs recognize murine CD1.
Authors: Authors: Behar SM, Podrebarac TA, Roy CJ, Wang CR, Brenner MB.
J Immunol
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CD1-restricted microbial lipid antigen-specific recognition found in the CD8+ alpha beta T cell pool.
Authors: Authors: Rosat JP, Grant EP, Beckman EM, Dascher CC, Sieling PA, Frederique D, Modlin RL, Porcelli SA, Furlong ST, Brenner MB.
J Immunol
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