Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital

Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Migration of intestinal intraepithelial lymphocytes into a polarized epithelial monolayer.

Authors: Authors: Shaw SK, Hermanowski-Vosatka A, Shibahara T, McCormick BA, Parkos CA, Carlson SL, Ebert EC, Brenner MB, Madara JL.
Am J Physiol 1998-09-01
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The CD1 family of lipid antigen-presenting molecules.

Authors: Authors: Porcelli SA, Segelke BW, Sugita M, Wilson IA, Brenner MB.
Immunol Today 1998-08-01
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Crucial role of TCR gamma chain junctional region in prenyl pyrophosphate antigen recognition by gamma delta T cells.

Authors: Authors: Bukowski JF, Morita CT, Band H, Brenner MB.
J Immunol 1998-07-01
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CD1--a new paradigm for antigen presentation and T cell activation.

Authors: Authors: Sugita M, Moody DB, Jackman RM, Grant EP, Rosat JP, Behar SM, Peters PJ, Porcelli SA, Brenner MB.
Clin Immunol Immunopathol 1998-04-01
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Clonally expanded Valpha12+ (AV12S1),CD8+ T cells from a patient with rheumatoid arthritis are autoreactive.

Authors: Authors: Behar SM, Roy C, Lederer J, Fraser P, Brenner MB.
Arthritis Rheum 1998-03-01
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Rifampin increases cytokine-induced expression of the CD1b molecule in human peripheral blood monocytes.

Authors: Authors: Tentori L, Graziani G, Porcelli SA, Sugita M, Brenner MB, Madaio R, Bonmassar E, Giuliani A, Aquino A.
Antimicrob Agents Chemother 1998-03-01
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Structure of the Vdelta domain of a human gammadelta T-cell antigen receptor.

Authors: Authors: Li H, Lebedeva MI, Llera AS, Fields BA, Brenner MB, Mariuzza RA.
Nature 1998-01-29
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Direct and regulated interaction of integrin alphaEbeta7 with E-cadherin.

Authors: Authors: Higgins JM, Mandlebrot DA, Shaw SK, Russell GJ, Murphy EA, Chen YT, Nelson WJ, Parker CM, Brenner MB.
J Cell Biol 1998-01-12
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Effect of rifampin on CD1b expression and double-negative T cell responses against mycobacteria-derived glycolipid antigen.

Authors: Authors: Giuliani A, Porcelli SA, Tentori L, Graziani G, Testorelli C, Prete SP, Bussini S, Cappelletti D, Brenner MB, Bonmassar E, Aquino A.
Life Sci 1998-01-01
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Cytotoxic T lymphocytes in resistance to tuberculosis.

Authors: Authors: Mazzaccaro RJ, Stenger S, Rock KL, Porcelli SA, Brenner MB, Modlin RL, Bloom BR.
Adv Exp Med Biol 1998-01-01
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