Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital
Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Effect of rifampin on CD1b expression and double-negative T cell responses against mycobacteria-derived glycolipid antigen.
Authors: Authors: Giuliani A, Porcelli SA, Tentori L, Graziani G, Testorelli C, Prete SP, Bussini S, Cappelletti D, Brenner MB, Bonmassar E, Aquino A.
Life Sci
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Assembly and retention of CD1b heavy chains in the endoplasmic reticulum.
Authors: Authors: Sugita M, Porcelli SA, Brenner MB.
J Immunol
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Antigen presentation: mixing oil and water.
Authors: Authors: Porcelli SA, Brenner MB.
Curr Biol
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Differential effects of cytolytic T cell subsets on intracellular infection.
Authors: Authors: Stenger S, Mazzaccaro RJ, Uyemura K, Cho S, Barnes PF, Rosat JP, Sette A, Brenner MB, Porcelli SA, Bloom BR, Modlin RL.
Science
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Cytokine-induced expression of CD1b molecules by peripheral blood monocytes: influence of 3'-azido-3'-deoxythymidine.
Authors: Authors: Giuliani A, Tentori L, Pepponi R, Porcelli SA, Aquino A, Orlando L, Sugita M, Brenner MB, Bonmassar E, Graziani G.
Pharmacol Res
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The mannose receptor delivers lipoglycan antigens to endosomes for presentation to T cells by CD1b molecules.
Authors: Authors: Prigozy TI, Sieling PA, Clemens D, Stewart PL, Behar SM, Porcelli SA, Brenner MB, Modlin RL, Kronenberg M.
Immunity
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Cloning, expression, and crystallization of the V delta domain of a human gamma delta T-cell receptor.
Authors: Authors: Lebedeva MI, Fields BA, Spits H, Panchamoorthy G, Brenner MB, Mariuzza RA.
Protein Sci
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p126 (CDw101), a costimulatory molecule preferentially expressed on mucosal T lymphocytes.
Authors: Authors: Russell GJ, Parker CM, Sood A, Mizoguchi E, Ebert EC, Bhan AK, Brenner MB.
J Immunol
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Cytoplasmic tail-dependent localization of CD1b antigen-presenting molecules to MIICs.
Authors: Authors: Sugita M, Jackman RM, van Donselaar E, Behar SM, Rogers RA, Peters PJ, Brenner MB, Porcelli SA.
Science
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Expression of a candidate cadherin in T lymphocytes.
Authors: Authors: Cepek KL, Rimm DL, Brenner MB.
Proc Natl Acad Sci U S A
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