Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital

Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Direct presentation of non-peptide prenyl pyrophosphate antigens to human gamma delta T cells.

Authors: Authors: Morita CT, Tanaka Y, Bloom BR, Brenner MB.
Res Immunol 1996-06-01
View full abstract on Pubmed

Recognition of nonpeptide antigens by T cells.

Authors: Authors: Tanaka Y, Brenner MB, Bloom BR, Morita CT.
J Mol Med (Berl) 1996-05-01
View full abstract on Pubmed

Interactions of human alpha/beta and gamma/delta T lymphocyte subsets in shear flow with E-selectin and P-selectin.

Authors: Authors: Diacovo TG, Roth SJ, Morita CT, Rosat JP, Brenner MB, Springer TA.
J Exp Med 1996-03-01
View full abstract on Pubmed

Antigen presentation by CD1 and MHC-encoded class I-like molecules.

Authors: Authors: Melián A, Beckman EM, Porcelli SA, Brenner MB.
Curr Opin Immunol 1996-03-01
View full abstract on Pubmed

The CD1-restricted T-cell response to mycobacteria.

Authors: Authors: Moody DB, Sugita M, Peters PJ, Brenner MB, Porcelli SA.
Res Immunol 1996-01-01
View full abstract on Pubmed

A pathway of costimulation that prevents anergy in CD28- T cells: B7-independent costimulation of CD1-restricted T cells.

Authors: Authors: Behar SM, Porcelli SA, Beckman EM, Brenner MB.
J Exp Med 1995-12-01
View full abstract on Pubmed

Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells.

Authors: Authors: Morita CT, Beckman EM, Bukowski JF, Tanaka Y, Band H, Bloom BR, Golan DE, Brenner MB.
Immunity 1995-10-01
View full abstract on Pubmed

The beta 7 integrins in mucosal homing and retention.

Authors: Authors: Shaw SK, Brenner MB.
Semin Immunol 1995-10-01
View full abstract on Pubmed

CD1-restricted T cell recognition of microbial lipoglycan antigens.

Authors: Authors: Sieling PA, Chatterjee D, Porcelli SA, Prigozy TI, Mazzaccaro RJ, Soriano T, Bloom BR, Brenner MB, Kronenberg M, Brennan PJ, et al.
Science 1995-07-14
View full abstract on Pubmed

Expansions of V alpha 12 CD8+ T-cells in rheumatoid arthritis.

Authors: Authors: Behar SM, Roy C, Brenner MB.
Ann N Y Acad Sci 1995-07-07
View full abstract on Pubmed