Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital

Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

T-cell receptor V beta gene usage in rheumatoid synovial follicles.

Authors: Authors: Travaglio-Encinozal A, Dersimonian H, Jorgensen C, Romagné F, Sany J, D'Angeac AD, Brenner MB, Rème T.
Ann N Y Acad Sci 1995-07-07
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MHC class I-like, class II-like and CD1 molecules: distinct roles in immunity.

Authors: Authors: Beckman EM, Brenner MB.
Immunol Today 1995-07-01
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Natural and synthetic non-peptide antigens recognized by human gamma delta T cells.

Authors: Authors: Tanaka Y, Morita CT, Tanaka Y, Nieves E, Brenner MB, Bloom BR.
Nature 1995-05-11
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T cell receptor distribution in rheumatoid synovial follicles.

Authors: Authors: Travaglio-Encinoza A, Chaouni I, Dersimonian H, Jorgensen C, Simony-Lafontaine J, Romagné F, Sany J, Dupuy d'Angeac AD, Brenner MB, Rème T.
J Rheumatol 1995-03-01
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V gamma 2V delta 2 TCR-dependent recognition of non-peptide antigens and Daudi cells analyzed by TCR gene transfer.

Authors: Authors: Bukowski JF, Morita CT, Tanaka Y, Bloom BR, Brenner MB, Band H.
J Immunol 1995-03-01
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Association of the invariant chain with major histocompatibility complex class I molecules directs trafficking to endocytic compartments.

Authors: Authors: Sugita M, Brenner MB.
J Biol Chem 1995-01-20
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Recognition of a lipid antigen by CD1-restricted alpha beta+ T cells.

Authors: Authors: Beckman EM, Porcelli SA, Morita CT, Behar SM, Furlong ST, Brenner MB.
Nature 1994-12-15
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Recognition and destruction of virus-infected cells by human gamma delta CTL.

Authors: Authors: Bukowski JF, Morita CT, Brenner MB.
J Immunol 1994-12-01
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An unstable beta 2-microglobulin: major histocompatibility complex class I heavy chain intermediate dissociates from calnexin and then is stabilized by binding peptide.

Authors: Authors: Sugita M, Brenner MB.
J Exp Med 1994-12-01
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Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin.

Authors: Authors: Cepek KL, Shaw SK, Parker CM, Russell GJ, Morrow JS, Rimm DL, Brenner MB.
Nature 1994-11-10
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